Estimating the amount of FDG uptake in physiological tissues.
Nuclear Medicine and Biology. 2014-10-01; 41(9): 717-720
DOI: 10.1016/j.nucmedbio.2014.06.003
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1. Nucl Med Biol. 2014 Oct;41(9):717-20. doi: 10.1016/j.nucmedbio.2014.06.003. Epub
2014 Jun 24.
Estimating the amount of FDG uptake in physiological tissues.
Laffon E(1), de Clermont H(2), Lamare F(2), Marthan R(3).
Author information:
(1)CHU de Bordeaux, Service de Médecine Nucléaire, F-33604 Pessac, France;
Université de Bordeaux 2, Centre de Recherche Cardio-Thoracique, F-33076
Bordeaux, France; INSERM U 1045, Centre de Recherche Cardio-Thoracique, F-33076
Bordeaux, France. Electronic address: .
(2)CHU de Bordeaux, Service de Médecine Nucléaire, F-33604 Pessac, France.
(3)Université de Bordeaux 2, Centre de Recherche Cardio-Thoracique, F-33076
Bordeaux, France; INSERM U 1045, Centre de Recherche Cardio-Thoracique, F-33076
Bordeaux, France.
INTRODUCTION: It is known that for a fixed amount of injected tracer, the amount
available for a tissue of interest will be less if other tissues show intense
uptake. The aim of this study was to estimate the magnitude of
2-deoxy-2-[(18)F]fluoro-D-glucose (18FDG) uptake amount in physiological tissues
that may show an intense uptake in current clinical practice.
METHODS: A formula was established providing an estimate of the percentage of
injected 18FDG molecules (P; in %) that are irreversibly trapped in an
18FDG-positive tissue during a PET examination.
RESULTS: P ≅ 0.17*exp(-λt(acq))*TLG/W, where λ is the (18)F physical decay
constant, t(acq) is the injection-acquisition time delay, TLG is total lesion
glycolysis (g) and W is the patient weight (kg). The magnitude of P was
calculated in two patients showing an intense uptake in brown fat, myocardium and
bowels: 0.5, 3.5, and 4.2% respectively.
CONCLUSIONS: A formula is available to quickly estimate the amount of 18FDG
uptake in tissues. We suggest that the accumulation of different physiological
uptakes may actually affect SUV quantification in a tissue of interest.
Copyright © 2014 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.nucmedbio.2014.06.003
PMID: 25073424 [Indexed for MEDLINE]