Erythropoietin, a cytoprotective and regenerative cytokine, and the hypoxic brain.
Neurodegener Dis. 2006-01-01; 3(1-2): 87-93
DOI: 10.1159/000092098
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1. Neurodegener Dis. 2006;3(1-2):87-93.
Erythropoietin, a cytoprotective and regenerative cytokine, and the hypoxic
brain.
Pacary E(1), Petit E, Bernaudin M.
Author information:
(1)UMR-CNRS 6185, University of Caen, Caen, France.
Hypoxia and ischemia in the brain often result in brain dysfunctions and neuronal
death during both the neonatal and adult periods. Though the mechanisms
contributing to brain injury secondary to hypoxia-ischemia are more clearly
defined, there are still no pharmacological treatments available to reduce cell
death in the ischemic brain. This review highlights the beneficial effects of
hypoxia-inducible factors, such as the transcriptional factor hypoxia-inducible
factor-1 and its target genes, as both cytoprotective and regenerative factors,
and focuses in particular on one of the most well-known: erythropoietin.
Altogether, the data presented in this review suggest that further insights into
the role of hypoxia-inducible factors would help develop promising strategies to
improve the outcome of hypoxia/ischemia-related brain pathologies.
Copyright (c) 2006 S. Karger AG, Basel.
DOI: 10.1159/000092098
PMID: 16909042 [Indexed for MEDLINE]