Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF
Neurobiology of Learning and Memory. 2011-09-01; 96(2): 121-129
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1. Neurobiol Learn Mem. 2011 Sep;96(2):121-9. doi: 10.1016/j.nlm.2011.03.004. Epub
2011 Apr 2.
Enriched housing reverses age-associated impairment of cognitive functions and
tPA-dependent maturation of BDNF.
Obiang P(1), Maubert E, Bardou I, Nicole O, Launay S, Bezin L, Vivien D, Agin V.
(1)INSERM, INSERM U919, SP(2)U, Centre for Imaging-Neuroscience and Applications
to Pathologies, GIP CYCERON, University of Caen Basse-Normandie (UCBN), F-14074
Caen Cedex, France.
Although tissue type plasminogen activator (tPA) and brain derived neurotrophic
factor (BDNF) have been extensively described to influence brain outcomes in a
number of disorders, their roles during physiological aging are poorly
investigated. In the present study, we investigated whether maintenance of mice
in different environmental conditions could influence age-associated changes in
hippocampal tPA expression and BDNF maturation in relation with modifications of
their cognitive performances. Our data indicate that maintenance in enriched
housing led to a reversal of age-associated decrease in expression of hippocampal
tPA. A subsequent increase in the level of mature BDNF and an improvement in
emotional and spatial memories were observed. Taken together, these data suggest
that the tPA-BDNF axis could play a critical role in the control of cognitive
functions influenced both by the age and housing conditions.
Copyright © 2011 Elsevier Inc. All rights reserved.
PMID: 21440650 [Indexed for MEDLINE]