Endocytic trafficking and recycling maintain a pool of mobile surface AMPA receptors required for synaptic potentiation.
Neuron. 2009-07-01; 63(1): 92-105
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1. Neuron. 2009 Jul 16;63(1):92-105. doi: 10.1016/j.neuron.2009.05.025.
Endocytic trafficking and recycling maintain a pool of mobile surface AMPA
receptors required for synaptic potentiation.
Petrini EM(1), Lu J, Cognet L, Lounis B, Ehlers MD, Choquet D.
(1)Laboratoire Physiologie Cellulaire de la Synapse, University of Bordeaux and
CNRS, Bordeaux, France.
At excitatory glutamatergic synapses, postsynaptic endocytic zones (EZs), which
are adjacent to the postsynaptic density (PSD), mediate clathrin-dependent
endocytosis of surface AMPA receptors (AMPAR) as a first step to receptor
recycling or degradation. However, it remains unknown whether receptor recycling
influences AMPAR lateral diffusion and whether EZs are important for the
expression of synaptic potentiation. Here, we demonstrate that the presence of
both EZs and AMPAR recycling maintain a large pool of mobile AMPARs at synapses.
In addition, we find that synaptic potentiation is accompanied by an accumulation
and immobilization of AMPARs at synapses resulting from both their exocytosis and
stabilization at the PSD. Displacement of EZs from the postsynaptic region
impairs the expression of synaptic potentiation by blocking AMPAR recycling.
Thus, receptor recycling is crucial for maintaining a mobile population of
surface AMPARs that can be delivered to synapses for increases in synaptic
PMID: 19607795 [Indexed for MEDLINE]