Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat
Neuroscience. 2000-09-01; 99(2): 289-295
DOI: 10.1016/S0306-4522(00)00199-8
Read on PubMed
1. Neuroscience. 2000;99(2):289-95. doi: 10.1016/s0306-4522(00)00199-8.
Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal
activities of the substantia nigra pars reticulata and ventrolateral nucleus of
the thalamus in the rat.
Benazzouz A(1), Gao DM, Ni ZG, Piallat B, Bouali-Benazzouz R, Benabid AL.
Author information:
(1)Laboratoire de Neurobiologie préclinique, INSERM U. 318, CHU-Pavillon B, BP
217, 38043, Grenoble, France.
Electrophysiological recordings were made in anaesthetized rats to investigate
the mode of function of high-frequency stimulation of the subthalamic nucleus
used as a therapeutic approach for Parkinson’s disease. High-frequency
electrical stimulation of the subthalamic nucleus (130 Hz) induced a net
decrease in activity of all cells recorded around the site of stimulation in the
subthalamic nucleus. It also caused an inhibition of the majority of neurons
recorded in the substantia nigra pars reticulata in normal rats (94%) and in
rats with 6-hydroxydopamine lesions of the substantia nigra pars compacta (90%)
or with ibotenic acid lesions of the globus pallidus (79.5%). The majority of
cells recorded in the ventrolateral nucleus of the thalamus responded with an
increase in their activity (84%). These results show that high-frequency
stimulation of the subthalamic nucleus induces a reduction of the excitatory
glutamatergic output from the subthalamic nucleus which results in deactivation
of substantia nigra pars reticulata neurons. The reduction in tonic inhibitory
drive of nigral neurons induces a disinhibition of activity in the ventrolateral
motor thalamic nucleus, which should result in activation of the motor cortical
system.
DOI: 10.1016/s0306-4522(00)00199-8
PMID: 10938434 [Indexed for MEDLINE]