Early onset schizophrenia and partial agenesis of corpus callosum | Schizophrénie à début précoce et agénésie partielle du corps calleux
Archives de Pédiatrie. 2011-02-01; 18(2): 189-192
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1. Arch Pediatr. 2011 Feb;18(2):189-92. doi: 10.1016/j.arcped.2010.11.015. Epub 2011
[Early onset schizophrenia and partial agenesis of corpus callosum].
[Article in French]
Micoulaud-Franchi JA(1), Bat-Pitault F, Da Fonseca D, Rufo M.
(1)Solaris, pôle universitaire de psychiatrie, hôpital Sainte-Marguerite,
We report a case of schizophrenia with partial agenesis of the corpus callosum in
a 14-year-old girl. Diagnosis of schizophrenia was confirmed in the longitudinal
follow-up and partial agenesis of the corpus callosum was found on brain MRI at
the prodromal stage of disease. The prodromal symptom was progressive
deterioration of social and academic adjustment in a context of non-specified
psychotic disorder in the father. We found no abnormality in the development but
a history of seizures that did not require specific treatment. Follow-up at 8
months showed an increase in negative symptoms and the onset of delusional
symptoms and disorganization leading to the prescription of antipsychotic
treatment. A review of the literature shows that agenesis of corpus callosum is
the most reliable brain morphology abnormality in schizophrenia and is related to
the neurodevelopmental and abnormal brain connectivity hypothesis in
schizophrenia. Although this abnormality may be a marker of disease severity, our
case report highlights the lack of longitudinal follow-up to allow the
characterization of a specific outcome pattern of schizophrenic adolescents with
partial agenesis of the corpus callosum.
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
PMID: 21215603 [Indexed for MEDLINE]