Early Fiber Number Ratio Is a Surrogate of Corticospinal Tract Integrity and Predicts Motor Recovery After Stroke.
Stroke. 2016-03-15; 47(4): 1053-1059
DOI: 10.1161/strokeaha.115.011576
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1. Stroke. 2016 Apr;47(4):1053-9. doi: 10.1161/STROKEAHA.115.011576. Epub 2016 Mar
15.
Early Fiber Number Ratio Is a Surrogate of Corticospinal Tract Integrity and
Predicts Motor Recovery After Stroke.
Bigourdan A(1), Munsch F(1), Coupé P(1), Guttmann CR(1), Sagnier S(1), Renou
P(1), Debruxelles S(1), Poli M(1), Dousset V(1), Sibon I(1), Tourdias T(2).
Author information:
(1)From the Université de Bordeaux, Bordeaux, France (A.B., F.M., P.C., C.R.G.G.,
V.D., I.S., T.T.); CHU de Bordeaux, Neuroimagerie Diagnostique et Thérapeutique,
Bordeaux, France (A.B., F.M., V.D., T.T.); INSERM, U1215, Neurocentre Magendie,
Bordeaux, France (F.M., V.D., T.T.); LaBRI, UMR 5800, PICTURA, Talence, France
(P.C.); Center for Neurological Imaging, Brigham and Women’s Hospital, Harvard
Medical School, Boston, MA (C.R.G.G.); CHU de Bordeaux, Unité Neurovasculaire,
Bordeaux, France (S.S., P.R., S.D., M.P., I.S.); and INCIA, UMR 5287, Bordeaux,
France (I.S.).
(2)From the Université de Bordeaux, Bordeaux, France (A.B., F.M., P.C., C.R.G.G.,
V.D., I.S., T.T.); CHU de Bordeaux, Neuroimagerie Diagnostique et Thérapeutique,
Bordeaux, France (A.B., F.M., V.D., T.T.); INSERM, U1215, Neurocentre Magendie,
Bordeaux, France (F.M., V.D., T.T.); LaBRI, UMR 5800, PICTURA, Talence, France
(P.C.); Center for Neurological Imaging, Brigham and Women’s Hospital, Harvard
Medical School, Boston, MA (C.R.G.G.); CHU de Bordeaux, Unité Neurovasculaire,
Bordeaux, France (S.S., P.R., S.D., M.P., I.S.); and INCIA, UMR 5287, Bordeaux,
France (I.S.). .
BACKGROUND AND PURPOSE: The contribution of imaging metrics to predict poststroke
motor recovery needs to be clarified. We tested the added value of early
diffusion tensor imaging (DTI) of the corticospinal tract toward predicting
long-term motor recovery.
METHODS: One hundred seventeen patients were prospectively assessed at 24 to 72
hours and 1 year after ischemic stroke with diffusion tensor imaging and motor
scores (Fugl-Meyer). The initial fiber number ratio (iFNr) and final fiber number
ratio were computed as the number of streamlines along the affected corticospinal
tract normalized to the unaffected side and were compared with each other. The
prediction of motor recovery (ΔFugl-Meyer) was first modeled using initial
Fugl-Meyer and iFNr. Multivariate ordinal logistic regression models were also
used to study the association of iFNr, initial Fugl-Meyer, age, and stroke volume
with Fugl-Meyer at 1 year.
RESULTS: The iFNr correlated with the final fiber number ratio at 1 year (r=0.70;
P