Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets
Molecular and Cellular Endocrinology. 2008-04-01; 286(1-2): S66-S78
DOI: 10.1016/j.mce.2008.01.026
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1. Mol Cell Endocrinol. 2008 Apr 16;286(1-2 Suppl 1):S66-78. doi:
10.1016/j.mce.2008.01.026. Epub 2008 Feb 9.
Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity:
Effect of high fat diets.
Matias I(1), Petrosino S, Racioppi A, Capasso R, Izzo AA, Di Marzo V.
Author information:
(1)Endocannabinoid Research Group, Institute of Biomolecular Chemistry,
Consiglio Nazionale delle Ricerche, Pozzuoli (NA), Italy.
Increasing evidence indicates that endocannabinoid (EC) signalling is
dysregulated during hyperglycemia and obesity, particularly at the level of
anandamide (AEA) and/or 2-arachidonoylglycerol (2-AG) concentrations in tissues
involved in the control of energy intake and processing, such as the liver,
white adipose tissue and pancreas. Here we review this previous evidence and
provide new data on the possible dysregulation of EC levels in organs with
endocrine function (adrenal glands and thyroid), involved in energy expenditure
(brown adipose tissue and skeletal muscle), or affected by the consequences of
metabolic disorders (heart and kidney), obtained from mice fed for 3, 8 and 14
weeks with two different high fat diets (HFDs), with different fatty acid
compositions and impact on fasting glucose levels. Statistically significant
elevations (in the skeletal muscle, heart and kidney) or reductions (in the
thyroid) of the levels of either AEA or 2-AG, or both, were found. Depending on
the diet, these changes preceded or accompanied the development of overt obesity
and/or hyperglycemia. In the adrenal gland, first a reduction and then an
elevation of EC levels were observed. In the brown fat, a very early elevation
of both AEA and 2-AG normalized levels was observed with one of the diets,
whereas delayed decreases were explained by an increase of the amount of fat
tissue weight induced by the HFDs. The potential implications of these and
previous findings in the general framework of the proposed roles of the EC
system in the control of metabolic, endocrine and cardiovascular and renal
functions are discussed.
DOI: 10.1016/j.mce.2008.01.026
PMID: 18343566 [Indexed for MEDLINE]