Dynamics of endocytic vesicle creation.
Developmental Cell. 2005-11-01; 9(5): 581-592
DOI: 10.1016/j.devcel.2005.10.002
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1. Dev Cell. 2005 Nov;9(5):581-92.
Dynamics of endocytic vesicle creation.
Perrais D(1), Merrifield CJ.
Author information:
(1)Laboratoire de Physiologie Cellulaire de la Synapse, CNRS UMR 5091, Université
Bordeaux 2, Institut François Magendie, 146 rue Léo Saignat, 33077 Bordeaux
Cedex, France.
Clathrin-mediated endocytosis is the main path for receptor internalization in
metazoans and is essential for controlling cell integrity and signaling. It is
driven by a large array of protein and lipid interactions that have been
deciphered mainly by biochemical and genetic means. To place these interactions
into context, and ultimately build a fully operative model of endocytosis at the
molecular level, it is necessary to know the kinetic details of the role of each
protein in this process. In this review, we describe the recent efforts made, by
using live cell imaging, to define clear steps in the formation of endocytic
vesicles and to observe the recruitment of key proteins during membrane
invagination, the scission of a newly formed vesicle, and its movement away from
the plasma membrane.
DOI: 10.1016/j.devcel.2005.10.002
PMID: 16256734 [Indexed for MEDLINE]