Dynamic modular-level alterations of structural-functional coupling in clinically isolated syndrome.

Ismail Koubiyr, Pierre Besson, Mathilde Deloire, Julie Charre-Morin, Aurore Saubusse, Thomas Tourdias, Bruno Brochet, Aurélie Ruet
Brain. 2019-09-05; 142(11): 3428-3439
DOI: 10.1093/brain/awz270

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Changes in both structural and functional connectivities are observed in multiple sclerosis, but little is known about how the evolution of one affects the other. Koubiyr et al. investigate the longitudinal multimodal reorganization of brain networks in the year following clinically isolated syndrome, and reveal structural-functional decoupling in several networks.

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