Dopamine D3 Receptor: Contemporary Views of Its Function and Pharmacology for Neuropsychiatric Diseases

Philippe De Deurwaerdère, Abdeslam Chagraoui
Biomolecules. 2021-05-11; 11(5): 713
DOI: 10.3390/biom11050713


Biomolecules has launched a Special Issue entitled “Dopamine D3 Receptor: Contemporary Views of Its Function and Pharmacology for Neuropsychiatric Diseases.” Since its discovery in 1990 by the group of Jean-Charles Schwartz, numerous studies have emphasized its brain location, its molecular partners and, more generally, its important roles in central dopaminergic transmission. Nowadays, D3Rs are strongly considered in the treatment of various central nervous system conditions, including schizophrenia, depression, addiction, Parkinson’s disease, and Alzheimer’s disease, to name a few. Numerous drugs acting at D3Rs have been released; some of them are selective, whereas others favor a multitarget approach . The field is progressing fast and in several directions. We have collected research and review articles highlighting interests to target D3Rs in neurological and neuropsychiatric conditions. (…)

Know more about