Dissociation of the Role of Infralimbic Cortex in Learning and Consolidation of Extinction of Recent and Remote Aversion Memory.
Neuropsychopharmacol. 2015-04-15; 40(11): 2566-2575
DOI: 10.1038/npp.2015.103
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1. Neuropsychopharmacology. 2015 Oct;40(11):2566-75. doi: 10.1038/npp.2015.103. Epub
2015 Apr 15.
Dissociation of the Role of Infralimbic Cortex in Learning and Consolidation of
Extinction of Recent and Remote Aversion Memory.
Awad W(1), Ferreira G(2)(3), Maroun M(1).
Author information:
(1)Sagol Department of Neurobiology, Faculty of Natural Sciences, University of
Haifa, Haifa, Israel.
(2)Nutrition and Integrative Neurobiology, INRA UMR 1286, Bordeaux, France.
(3)Université de Bordeaux, Bordeaux, France.
Medial prefrontal circuits have been reported to undergo a major reorganization
over time and gradually take a more important role for remote emotional memories
such as contextual fear memory or food aversion memory. The medial prefrontal
cortex, and specifically its ventral subregion, the infralimbic cortex (IL), was
also reported to be critical for recent memory extinction of contextual fear
conditioning and conditioned odor aversion. However, its exact role in the
extinction of remotely acquired information is still not clear. Using
postretrieval blockade of protein synthesis or inactivation of the IL, we showed
that the IL is similarly required for extinction consolidation of recent and
remote fear memory. However, in odor aversion memory, the IL was only involved in
extinction consolidation of recent, but not remote, memory. In contrast, only
remote retrieval of aversion memory induced c-Fos activation in the IL and
preretrieval inactivation of the IL with lidocaine impaired subsequent extinction
of remote but not recent memory, indicating IL is necessary for extinction
learning of remote aversion memory. In contrast to the effects in odor aversion,
our data show that the involvement of the IL in the consolidation of fear
extinction does not depend on the memory age. More importantly, our data indicate
that the IL is implicated in the extinction of fear and nonfear-based
associations and suggest dissociation in the engagement of the IL in the learning
and consolidation of food aversion extinction over time.
DOI: 10.1038/npp.2015.103
PMCID: PMC4569946
PMID: 25872918 [Indexed for MEDLINE]