Dissecting the cannabinergic control of behavior: The where matters.

Arnau Busquets-Garcia, Tifany Desprez, Mathilde Metna-Laurent, Luigi Bellocchio, Giovanni Marsicano, Edgar Soria-Gomez
BioEssays. 2015-08-11; 37(11): 1215-1225
DOI: 10.1002/bies.201500046

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1. Bioessays. 2015 Nov;37(11):1215-25. doi: 10.1002/bies.201500046. Epub 2015 Aug

Dissecting the cannabinergic control of behavior: The where matters.

Busquets-Garcia A(1), Desprez T(1), Metna-Laurent M(1), Bellocchio L(1),
Marsicano G(1), Soria-Gomez E(1).

Author information:
(1)Group “Endocannabinoids and Neuroadaptation,” NeuroCentre Magendie, INSERM
U862, University of Bordeaux, Bordeaux, France.

The endocannabinoid system is the target of the main psychoactive component of
the plant Cannabis sativa, the Δ(9)-tetrahydrocannabinol (THC). This system is
composed by the cannabinoid receptors, the endogenous ligands, and the enzymes
involved in their metabolic processes, which works both centrally and
peripherally to regulate a plethora of physiological functions. This review aims
at explaining how the site-specific actions of the endocannabinoid system impact
on memory and feeding behavior through the cannabinoid receptors 1 (CB1 R).
Centrally, CB1 R is widely distributed in many brain regions, different cell
types (e.g. neuronal or glial cells) and intracellular compartments (e.g.
mitochondria). Interestingly, cellular and molecular effects are differentially
mediated by CB1 R according to their cell-type localization (e.g. glutamatergic
or GABAergic neurons). Thus, understanding the cellular and subcellular function
of CB1 R will provide new insights and aid the design of new compounds in
cannabinoid-based medicine. Also watch the Video Abstract.

© 2015 WILEY Periodicals, Inc.


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