Disruption of the proprioceptive mapping in the medial wall of parkinsonian monkeys.
Ann Neurol.. 2002-10-24; 52(5): 581-587
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1. Ann Neurol. 2002 Nov;52(5):581-7.
Disruption of the proprioceptive mapping in the medial wall of parkinsonian
Escola L(1), Michelet T, Douillard G, Guehl D, Bioulac B, Burbaud P.
(1)Laboratoire de Neurophysiologie, Unité Mixte de Recherche Centre National de
Recherche Scientifique, 5543, Université Victor Segalen, 146 rue Léo Saignat,
33076 Bordeaux, France.
Parkinsonian patients present an impairment of proprioceptor-guided movement that
could imply abnormal processing in the frontal mesial cortex. To test this
hypothesis, we compared neuronal response to joint displacement in the
supplementary and presupplementary motor areas of two monkeys, before and after
the progressive establishment of an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)-induced parkinsonian syndrome. After MPTP administration, neurons were
activated by the passive movement of numerous joints in various directions and no
longer simply by one or two joints in one direction. This impairment of the
focused selection of proprioceptive inputs, imputable to dopamine depletion,
could impede motor planning and thus contribute to akinesia.
PMID: 12402255 [Indexed for MEDLINE]