Differential involvement of amygdala and cortical NMDA receptors activation upon encoding in odor fear memory.
Learn. Mem.. 2014-11-17; 21(12): 651-655
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1. Learn Mem. 2014 Nov 17;21(12):651-5. doi: 10.1101/lm.036558.114. Print 2014 Dec.
Differential involvement of amygdala and cortical NMDA receptors activation upon
encoding in odor fear memory.
Hegoburu C(1), Parrot S(1), Ferreira G(2), Mouly AM(3).
(1)Centre de Recherche en Neurosciences de Lyon, INSERM U1028, CNRS UMR5292,
University Lyon1, Lyon, France.
(2)INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France
Université de Bordeaux, Nutrition et Neurobiologie Intégrée, Bordeaux, France.
(3)Centre de Recherche en Neurosciences de Lyon, INSERM U1028, CNRS UMR5292,
University Lyon1, Lyon, France .
Although the basolateral amygdala (BLA) plays a crucial role for the acquisition
of fear memories, sensory cortices are involved in their long-term storage in
rats. However, the time course of their respective involvement has received
little investigation. Here we assessed the role of the glutamatergic
N-methyl-d-aspartate (NMDA) receptors in the BLA and olfactory cortex at discrete
moments of an odor fear conditioning session. We showed that NMDA receptors in
BLA are critically involved in odor fear acquisition during the first association
but not during the next ones. In the cortex, NMDA receptor activation at encoding
is not necessary for recent odor fear memory while its role in remote memory
storage needs further investigation.
© 2014 Hegoburu et al.; Published by Cold Spring Harbor Laboratory Press.
PMID: 25403452 [Indexed for MEDLINE]