Differential expression of the nm23 genes in the developing human trophoblast

F Guyon, B Marnet, S Arnaud-Dabernat, D Carles, C Mathieu, R Saura, Y Perel, J Horovitz, M Landry, P Bischof, J.Y Daniel
Placenta. 2004-01-01; 25(1): 20-28
DOI: 10.1016/j.placenta.2003.08.003

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1. Placenta. 2004 Jan;25(1):20-8.

Differential expression of the nm23 genes in the developing human trophoblast.

Guyon F(1), Marnet B, Arnaud-Dabernat S, Carles D, Mathieu C, Saura R, Perel Y,
Horovitz J, Landry M, Bischof P, Daniel JY.

Author information:
(1)Biologie de la Différenciation et du Développement, Université Victor
Segalen-Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux, France.

NDP kinases are the non-specific enzymes which catalyse the synthesis of the NTPs
through a transfer reaction using ATP as phosphoryl donor. In addition to their
enzymatic activity, they display other not yet explained functions related to
cell growth, differentiation and apoptosis, embryonic development, tumour
progression and metastasis. In this study, the expression patterns of the three
highly related NDP kinases A, B and C isoforms were investigated in the
developing human trophoblast. Both NDP kinase A and B were found to be primarily
present in the villous and extravillous cytotrophoblasts, while NDP kinase C was
found almost exclusively in the syncytiotrophoblast layer. This suggests that NDP
kinase A and B could be a marker for the mononuclear stage of differentiation of
villous trophoblasts, while NDP kinase C could be a marker of the
syncytiotrophoblast layer.

DOI: 10.1016/j.placenta.2003.08.003
PMID: 15013635 [Indexed for MEDLINE]

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