Determinants of voltage-gated sodium channel clustering in neurons.
Seminars in Cell & Developmental Biology. 2011-04-01; 22(2): 171-177
DOI: 10.1016/j.semcdb.2010.09.014
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1. Semin Cell Dev Biol. 2011 Apr;22(2):171-7. doi: 10.1016/j.semcdb.2010.09.014.
Epub 2010 Oct 8.
Determinants of voltage-gated sodium channel clustering in neurons.
Leterrier C(1), Brachet A, Dargent B, Vacher H.
Author information:
(1)INSERM UMR 641, Marseille, France.
In mammalian neurons, the generation and propagation of the action potential
result from the presence of dense clusters of voltage-gated sodium channels (Nav)
at the axonal initial segment (AIS) and nodes of Ranvier. In these two
structures, the assembly of specific supra-molecular complexes composed of
numerous partners, such as cytoskeletal scaffold proteins and signaling proteins
ensures the high concentration of Nav channels. Understanding how neurons
regulate the expression and discrete localization of Nav channels is critical to
understanding the diversity of normal neuronal function as well as neuronal
dysfunction caused by defects in these processes. Here, we review the mechanisms
establishing the clustering of Nav channels at the AIS and in the node and
discuss how the alterations of Nav channel clustering can lead to certain
pathophysiologies.
Copyright © 2010 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.semcdb.2010.09.014
PMID: 20934527 [Indexed for MEDLINE]