Detecting global and local hippocampal shape changes in Alzheimer’s disease using statistical shape models.
NeuroImage. 2012-02-01; 59(3): 2155-2166
DOI: 10.1016/j.neuroimage.2011.10.014
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Shen KK, Fripp J, Mériaudeau F, Chételat G, Salvado O, Bourgeat P; Alzheimer’s Disease Neuroimaging Initiative.
Collaborators: Saradha A, Abdi H, Abdulkadir A, Acharya D, Achuthan A, Adluru N,
Aghajanian J, Agrusti A, Agyemang A, Ahdidan J, Ahmad D, Ahmed S, Aisen P,
Akhondi-Asl A, Aksu Y, Alberca R, Alcauter S, Alexander D, Alin A, Almeida F,
Alvarez-Lineara J, Amlien I, Anand S, Anderson D, Ang A, Angersbach S, Ansarian
R, Aoyama E, Appannah A, Arfanakis K, Armor T, Arrighi M, Arumughababu Sv,
Arunagiri V, Ashe-McNalley C, Ashford W, Le Page A, Avants B, Aviv R, Awasthi S,
Ayache N, Ayan-Oshodi M, Ayhan M, Sumana BV, Babic T, Baek Y, Bagepally B, Baird
G, Baker J, Baker S, Bakker A, Barbash S, Bard J, Barker W, Bartlett J, Baruchin
A, Battaglini I, Bauer C, Bayley P, Beck I, Becker J, Becker JA, Beckett L,
Bednar M, Bedner A, Beg MF, Bekris L, Belaroussi B, Belloch V, Belmokhtar N, ben
Ahmed O, Bender JD, Benois-Pineau J, Bhaskar U, Bienkowska K, Biffi A, Bigler E,
Bilgic B, Bishop C, Bittner D, Black S, Bloss C, Bocti C, Bohorquez A, Bokde A,
Boone J, Boppana M, Borrie M, Bourgeat P, Bouttout H, Bowes M, Bowman D, Bowman
G, Bracard S, Braskie M, Braunewell K, Breitner J, Bresell A, Brewer J,
Brickhouse M, Brickman A, Britschgi M, Broadbent S, Brogren J, Brunton S,
Buchsbaum M, Buckley C, Buerger K, Bunce D, Burnham S, Burns J, Burton D,
Burzykowski T, Butler T, Cabeza R, Caffery T, Cairns N, Callhoff J, Calvini P,
Carbotti A, Carle A, Carmasin J, Carmichael O, Carvalho J, Casabianca J, Casanova
R, Casey A, Cash D, Cataldo R, Cedarbaum J, Cella M, Celsis P, Chakravarty M,
Chang I, Chao L, Charil A, Chang CW, Chemali Z, Chen K, Chen S, Chen R, Chen Q,
Chen JT, Chen G, Chen J, Chen W, Cheng WC, Cheng X, Cherkas Y, Chertkow H, Cheung
V, Cheung C, Chiang G, Chiao P, Chibane MB, Chida N, Chin S, Ching C, Chisholm J,
Cho C, Cho Y, Choe J, Choubey S, Chowbina S, Christensen AL, Ciocia G, Clark D,
Clark C, Clarkson M, Clerc S, Clunie D, Coen M, Ciombra A, Compton D, Coppola G,
Coubard O, Coulin S, Cover KS, Crane P, Crans G, Croop R, Crowther D, Crum W, Cui
Y, Curry C, Cutter G, Da L, Daliri MR, Damato VD, Darby E, Darkner S, Davatzikos
C, DavidPrakash B, Davidson C, Davis M, de Bruijne M, De Meyer G, De Nunzio G,
DeCarli C, Dechairo B, DeDuck K, Dehghan H, Delfino M, Della Rosa PA, Dellavedova
L, Delpassand E, Delrieu J, DeOrchis V, Dépy Carron D, Desjardins B,
deToledo-Morrell L, Devanand D, Devanarayan V, Devier D, Devous M, Dgetluck N, Di
J, Di X, Diaz-Arrastia R, Dickerson B, Dickie DA, Dill V, Ding X, Dinov I, Dobosh
B, Dobson H, Dodge H, Dolman A, Dolmo BC, Donohue M, Dore V, Dorflinger E,
Dowling M, Dragicevic N, Dubal D, Duchesne S, Duff K, Dukart J, Durazzo T, Dutta
J, DWors R, Earl N, Edula G, Elcoroaristizabal X, Emahazion T, Endres C, Epstein
N, Ereshefsky L, Eskildsen S, Espinosa A, Esposito M, Ewers M, Falcone G, Fan Y,
Fan J, Fan L, Farahibozorg S, Farb N, Fardo D, Farias S, Farnum M, Farrer L,
Fatke B, Faux N, Feldman H, Feldman S, Feldman B, Félix Z, Fennema-Notestine C,
Fernandes M, Fernandez E, Ferreira MJ, Ferrer E, Fetterman B, Figurski M, Fillit
H, Finch S, Fiot JB, Flenniken D, Fletcher E, Flores C, Longmire CF, Focke N,
Forman M, Forsythe A, Fox S, Fox-Bosetti S, Foxhall S, Franko E, Freeman R,
Friedrich CM, Friesenhahn M, Frisoni G, Fritzsche K, Fujimoto Y, Fujiwara K,
Fullerton T, Gaffour Y, Galvin B, Gamst A, Gao S, Garg G, Gaser C, Gastineau E,
Gattaz W, Gaubert M, Gauthier S, Gavett B, Ge T, Gemme G, Geraci J, Gholipour F,
Ghosh D, Ghosh S, Gieschke R, Gill R, Gillespie W, Gitelman D, Gkontra X, Gleason
C, Glymour MM, Godbey M, Gold B, Goldberg T, Goldman J, Gonzalez-Beltran A,
Goodro R, Gore C, Gorriz JM, Goto M, Grachev I, Gradkowski W, Grandey E, Grasela
T, Gray K, Greenberg B, Greicius M, Grill J, Gross A, Gross A, Grydeland H,
Guignot I, Guo Q, Guo LH, Guo H, Gupta V, Guyot J, Habeck C, Habte F, Haight T,
Hajaj C, Hajiesmaeili M, Hajjar I, Hammarstrom P, Hampel H, Han D, Han J, Han Z,
Hanna Y, Hao Y, Hardy P, Harvey D, Hasan MK, Hayashi T, Haynes JD, He H, He Y,
Head D, Heckemann R, Heegaard N, Heidebrink J, Hellyer P, Helwig M, Henderson D,
Herholz K, Herskovits AZ, Hess C, Hildenbrand M, Ming AY, Hobart J, Hochstetler
H, Hofer S, Hoffman J, Holder D, Hollingworth P, Holmes R, Hong Q, Honigberg L,
Hope T, Hoppin J, Hot P, Hou Y, Hsieh H, Hsu A, Hu X, Hu M, Hu W, Hua WY, Huang
S, Huang F, Huang Z, Huang CJ, Huang CC, Huang J, Hubbard R, Huentelman M,
Huppertz HJ, Hurko O, Hurt S, Hutchins J, Hwang S, Hyun J, Ifeachor E, Iglesias
M, Ikari Y, Ikonomidou V, Iman A, Imani F, Immermann F, Inlow M, Inoue L, Insel
P, Irizarry M, Ishibashi T, Ishii K, Ismail S, Ito K, Iturria-Medina Y, Iwatsubo
T, Jacks A, Jacobson M, Jacqmin P, Jaffe C, Jagust W, Janousova E, Jara H,
Jasperse B, Jedynak B, Jefferson A, Jennings JR, Jenq J, Jessen W, Jia F, Jiang
T, Jiao Y, Jing H, Johnson K, Johnson S, Johnson DK, Johnson J, Jones G, Jones M,
Jones R, Joshi S, Jouvent E, Juengling F, Julin P, Junjie Z, Kabilan M, Kadish B,
Kairui Z, Kam HJ, Kamboh MI, Kamer A, Kanakaraj S, Kanchev V, Kaneko T, Kaneta T,
Kang H, Kang JH, Kang J, Karageorgiou E, Karantzoulis S, Karlawish J, Katz E,
Kaushik SS, Kauwe J, Kawakami H, Kawashima S, Kaye E, Kazemi S, Ke H, Kelleher T,
Kennedy R, Keogh B, Kerchner G, Kerr D, Keshava N, Khalil I, Khalil A, Khondker
Z, Kihara T, Killeen N, Killiany R, Kim D, Kim H, Kim S, Kim JH, Kim A, Kim JH,
Kimberg D, Kimura T, King R, Kirby J, Kirsch W, Klimas M, Kline R, Kling M,
Klopfenstein E, Koen J, Koikkalainen J, Kokomoor A, Kong X, Koppel J, Korolev I,
Kotran N, Kowalczyk A, Krahnke T, Krams M, Kuceyeski A, Kuhl D, Kumar V, Roy PK,
Kuo J, Labrish C, Lai S, Lakatos A, Lalonde F, Lam OK, Lampron A, Landau S, Lane
R, Lane B, Langbaum J, Langford D, Lanius V, Latella M, Leahy R, an Lee J, Lee D,
Lee N, Lee S, Lee D, Lee G, Lefkimmiatis S, Lemaitre H, Lenfant P, Lenz R, Leong
J, Leoutsakos JM, Leung YY, Levey A, Li R, Li X, Li W, Li X, Li M, Li L, Li J, Li
G, Li Q, Li Y, Li J, Li J, Li Y, Li S, Liang K, Liang K, Liang P, Liang L, Liao
W, Liaquat S, Liberman G, Lin L, Lin AL, Lin F, Liu T, Liu D, Liu L, Liu H, Liu
S, Liu T, Liu X, Liu S, Liu L, Liu W, Liu G, Liu T, Liu Y, Liu C, Lo R, Lobanov
V, Lockhart A, Loewenstein D, Logovinsky V, Long M, Long Z, Long X, Looi J, Lu H,
Lu PH, Lucena N, Lukas C, Lukic A, Luo L, Luo X, Luo X, Lynch J, Ma SM, Mackin S,
Mada M, Madabhushi A, Maglio S, Mahanta MS, Maikusa N, Maldjian J, Mandal I,
Manjon J, Mantri N, Manzour A, Marchewka A, Marcus D, Margolin R, Marrett S,
Marshall G, Gonzalez AM, Torteya AM, Mather M, Mathis C, Mattei P, Matthews D,
McArdle J, McCarroll S, McEvoy L, McGeown W, McGinnis S, McGonigle J, McIntyre J,
McLaren D, McQuail J, Meadowcroft M, Meda S, Melie-Garcia L, Melrose R, Mendelson
A, Mendez M, Menendez E, Meng M, Meredith J, Metti A, Meyer C, Mez J, Mickael G,
Miftahof R, Mikula M, Miller M, Millikin C, Mintun M, Mirza M, Mistridis P,
Mitchell M, Mitsis E, Mon A, Moore D, Morabito FC, Birgani PM, Moratal D,
Morimoto B, Mormino E, Morris J, Mortamet B, Moscato P, Mueller K, Mueller S,
Mukherjee S, Mulder E, Mungas D, Munir K, Murayama S, Murphy M, Myers A, Sairam
N, Nagata K, Nair A, Nativio R, Nazarparvar B, Nazeri A, Nejad L, Nekooei S,
Nettiksimmons J, Neu S, Ng YB, Nguyen N, Nichols T, Nicodemus K, Niecko T,
Nielsen C, Nishio T, Nordstrom M, Noshad S, Notomi K, Novak N, Nutakki GC,
O’Bryant S, Obisesan T, Oh J, Okonkwo O, Olde Rikkert M, Oliveira A, Oliveira J,
Oliver R, Olmos S, Oltra J, Ortner M, Osadebey M, Ostrowitzki S, Overholser R,
Anishiya P, Chitra PK, Pa J, Palanisamy P, Pan S, Pan Z, Pande Y, Pardo J, Pardoe
H, Park Sh, Park S, Park L, Park H, Park MH, Parker C, Patel Y, Patil A, Patil M,
Pawlak M, Payoux P, Pearson J, Pell G, Peng Y, Pennec X, Pepin Jl, Pereira F,
Perneczky R, Petitti D, Petrella J, Peyrat JM, Ngoc PT, Phillips J, Phillips N,
Pian WT, Pierson R, Piovezan M, Pipitone J, Pirraglia E, Planes X, Podhorski A,
Pollari M, Pomara N, Pontecorvo M, Popov V, Poppenk J, Posner H, Potkin S, Potter
G, Potter E, Poulin S, Prastawa M, Prince J, Priya A, Pruessner J, Qiu W, Qu A,
Qualls CD, Quarg P, Quinlan J, Rabbia M, Rajagovindan R, Rajeesh R, Rallabandi
VP, Ramadubramani V, Ramage A, Ramirez A, Randolph C, Rao A, Rao H, Rao D,
Raubertas R, Ray D, Razak H, Reed B, Reid A, Reihac A, Reiner P, Reinsberger C,
Restrepo L, Retico A, Rhatigan L, Rhinn H, Rhoades E, Ribbens A, Richard E,
Richards J, Richter M, Riddle W, Ridgway G, Ries M, Ringman J, Rischall M,
Rizk-Jackson A, Rizzi M, Robieson W, Rodriguez L, Rodriguez-Vieitez E, Rogalski
E, Rogers E, Balderrama JR, Rokicki J, Romero K, Rorden C, Rosand J, Rosen O,
Rosenberg P, Roubini E, Rousseau F, Rowe C, Rubin D, Rubright J, Rucinski M, Ruiz
A, Rulseh A, Rusinek H, Ryan L, Saad A, Sabuncu M, Sahuquillo J, Said Y, Saito N,
Sakata M, Salama M, Salazar D, Salter H, Saman S, Sanchez L, Sanders E, Sankar T,
Santhamma S, Sarnel H, Sasaki T, Sasaya T, Sato H, Sattlecker M, Saumier D, Savio
A, Saykin A, Scanlon B, Scharre D, Schegerin M, Schmand B, Schmansky N,
Schmidt-Wilcke T, Schramm H, Schuerch M, Schwartz C, Schwartz E, Schwarz A,
Schwarz J, Selnes P, Sembritzki K, Senjem M, Sevigny J, Sfikas G, Sghedoni R,
Shah SK, Shahbaba B, Shams S, Shankle W, Shattuck D, Shaw L, Sheela J, Shen J,
Shen Q, Shen W, Shen Q, Shera D, Sherman J, Sherva R, Shi J, Shi Y, Shi F,
Shokouhi S, Shukla V, Shulman J, Sideris K, Siegel R, Silveira M, Silverman D,
Sim I, Simak A, Simmons A, Simoes R, Simon A, Simon M, Simpson I, Singh N, Singh
SP, Sinha N, Siuciak J, Sjögren N, Skinner J, Smith M, Smith C, Smyth T, Snow S,
Snyder P, Soares H, Soldan A, Soldea O, Solomon A, Solomon P, Som S, Song Z, Song
S, Sosova I, Soydemir M, Spampinato MV, Speier W, Sperling R, Renãâ S, Spies L,
Springate B, Staff R, Steffener J, Stern Y, Stokman H, Straw J, Stricker N,
Stühler E, Styren S, Subramanian V, Suen S, Sugishita M, Sukkar R, Sun Y, Sun J,
Sun Y, Sundell K, Suzuki A, Svetnik V, Swan M, Symons S, Szigeti K, Szoeke C,
Sørensen L, Genish T, Takahasi T, Takeuchi T, Tanaka S, Tanaka R, Tanchi C,
Tancredi D, Tang Q, Tarnow E, Tartaglia MC, Tarver E, Tassy D, Tauber C,
Taylor-Reinwald L, Teipel S, Teng E, Terriza F, Thambisetty M, Thames A,
Thatavarti RS, Thiele F, Thomas C, Thomas R, Thomas B, Thompson P, Thompson W,
Thornton-Wells T, Thorvaldsson V, Thurfjell L, Tokuda T, Toledo JB, Tölli T, Toma
A, Tomita N, Toro R, Torrealdea P, Tosto G, Tosun D, Tousian M, Toussaint P,
Toyoshiba H, Tractenberg RE, Triggs T, Trittschuh E, Trojanowski J, Trotta G, Huu
TT, Truran D, Tsanas A, Tsang C, Tufail A, Tung J, Turken A, Ueda Y, Uematsu D,
Ullrich L, Venkataraju KU, Umar N, Ungar L, Uzunbas G, Van de Nes J, van der Brug
M, van der Lijn F, Van Hecke W, Van Horn J, Van Leemput K, Van Train K, Varkuti
B, Vasanawala M, Veeraraghavan H, Vemuri P, Verma M, Videbaek C, Vidoni E,
Villanueva-Meyer J, Vinyes G, Visser PJ, Vitek M, Vogel S, Voineskos A, Vos S,
Vounou M, Wade S, Walsh A, Wan H, Wang T, Wang YM, Wang W, Wang A, Wang S, Wang
L, Wang L, Wang Y, Wang LS, Wang L, Wang A, Wang Y, Wang X, Wang Z, Wang T, Ward
M, Ward A, Watanabe T, Watson D, Webb D, Wefel J, Weiner M, Westlye LT, Wheland
D, Whitcher B, White B, Whitlow C, Wilhelmsen K, Wilmot B, Wilson L, Wimsatt M,
Wingo T, Wirth M, Wishart H, Wiste H, Wolf H, Wolke I, Wolz R, Wong K, Woo J, Woo
E, Woods L, Worth A, Wu Y, Wu L, Wu E, Wyman B, Xiao G, Xie S, Xu Y, Xu YZ, Xu G,
Xu S, Xu S, Xu J, Yamada T, Yamashita F, Yan Y, Yan P, Yan Y, Yang CY, Yang Z,
Yang E, Yang G, Yang W, Yang E, Yank HD, Yang J, Yassa M, Yavorsky C, Ye BS, Ye
L, Ye J, Yee L, Ying S, Yokoyama T, Young S, Young J, Younhyun J, Yu D, Yu S, Yu
CQ, Yu P, Yuan Y, Yuan K, Yuan G, Yuen B, Yushkevich P, Zaborszky L, Zagorodnov
V, Zagorski M, Zahodne L, Zarei M, Zawadzki R, Zeitzer J, Zelinski E, Zeskind B,
Zhan S, Zhang J, Zhang L, Zhang Z, Zhang L, Zhang Z, Zhang D, Zhang H, Zhang X,
Zhang T, Zhang P, Zhao J, Zhao Q, Zhao P, Zhen X, Zhijun Y, Zhou L, Zhou B, Zhou
Y, Zhou S, Zhu H, Zhu W, Zhu W, Zhu X, Ziegler G, Zilka S, Zisserman A, Zito G,
Zu C, Zulfigar A.
The hippocampus is affected at an early stage in the development of Alzheimer’s
disease (AD). With the use of structural magnetic resonance (MR) imaging, we can
investigate the effect of AD on the morphology of the hippocampus. The
hippocampal shape variations among a population can be usually described using
statistical shape models (SSMs). Conventional SSMs model the modes of variations
among the population via principal component analysis (PCA). Although these modes
are representative of variations within the training data, they are not
necessarily discriminative on labeled data or relevant to the differences between
the subpopulations. We use the shape descriptors from SSM as features to classify
AD from normal control (NC) cases. In this study, a Hotelling’s T2 test is
performed to select a subset of landmarks which are used in PCA. The resulting
variation modes are used as predictors of AD from NC. The discrimination ability
of these predictors is evaluated in terms of their classification performances
with bagged support vector machines (SVMs). Restricting the model to landmarks
with better separation between AD and NC increases the discrimination power of
SSM. The predictors extracted on the subregions also showed stronger correlation
with the memory-related measurements such as Logical Memory, Auditory Verbal
Learning Test (AVLT) and the memory subscores of Alzheimer Disease Assessment
Scale (ADAS).