Design of Experiments and Sobol’ sensitivity analysis of a hippocampus computational model

Amelie Aussel, Laure Buhry, Radu Ranta
2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). 2021-11-01; :
DOI: 10.1109/embc46164.2021.9630725

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Aussel A, Buhry L, Ranta R.

The hippocampus is a brain area involved in many memory processes. This
structure can also be affected in neurological diseases such as mesial temporal
lobe epilepsy. A better understanding of its electrophysiological activity could
benefit both the neuroscientific and clinical communities. We proposed, in a
previous paper, a detailed bio-realistic conductance-based mathematical model of
more than thirty thousand neurons to reproduce the main oscillatory features of
the healthy hippocampus during slow-wave sleep and wakefulness, from slow to
very fast frequencies. One big challenge of this model is its parametrization.
The aim of the present work is to combine neuroscientific expertise and
systematic yet efficient exploration of the highly dimensional parameter space
using well defined identification methods, namely the design of experiments and
the Sobol’s sensitivity analysis.


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