Descriptive epidemiology of CNS tumors in France: results from the Gironde Registry for the period 2000-2007.
Neuro-Oncology. 2011-10-06; 13(12): 1370-1378
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1. Neuro Oncol. 2011 Dec;13(12):1370-8. doi: 10.1093/neuonc/nor120. Epub 2011 Oct 6.
Descriptive epidemiology of CNS tumors in France: results from the Gironde
Registry for the period 2000-2007.
Baldi I(1), Gruber A, Alioum A, Berteaud E, Lebailly P, Huchet A, Tourdias T,
Kantor G, Maire JP, Vital A, Loiseau H; Gironde TSNC Registry Group.
Collaborators: Champeaux K, Dhauteribes M, Eimer S, Gimbert E, Liguoro D, Monteil
P, Penchet G, San-Galli F, Vignes JR.
(1)Laboratoire Santé Travail Environnement, Centre INSERM U 897, Université
Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux, France.
An increase in the incidence of CNS tumors has been observed in many countries in
the last decades. The reality of this trend has been much debated, as it has
happened during a period when computer-assisted tomography and MRI have
dramatically improved the detection of these tumors. The Gironde CNS Tumor
Registry provides here the first data on CNS tumor incidence and trends in France
for all histological types, including benign and malignant tumors, for the period
2000-2007. Incidence rates were calculated globally and for each histological
subtype. For trends, a piecewise log-linear model was used. The overall annual
incidence rate was found to be 17.6/100 000. Of this rate, 7.9/100 000 were
neuroepithelial tumors and 6.0/100 000 were meningiomas. An overall increase in
CNS tumor incidence was observed from 2000 to 2007, with an annual percent change
(APC) of +2.33%, which was explained mainly by an increase in the incidence of
meningiomas over the 8-year period (APC = +5.4%), and also more recently by an
increase in neuroepithelial tumors (APC = +7.45% from 2003). The overall increase
was more pronounced in women and in the elderly, with an APC peaking at +24.65%
in subjects 85 and over. The increase in the incidence rates we observed may have
several explanations: not only improvements in registration, diagnosis, and
clinical practice, but also changes in potential risk factors.
PMID: 21980160 [Indexed for MEDLINE]