Depressive symptoms in obesity: Relative contribution of low-grade inflammation and metabolic health.
Psychoneuroendocrinology. 2018-05-01; 91: 55-61
DOI: 10.1016/j.psyneuen.2018.02.030
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1. Psychoneuroendocrinology. 2018 May;91:55-61. doi: 10.1016/j.psyneuen.2018.02.030.
Epub 2018 Mar 6.
Depressive symptoms in obesity: Relative contribution of low-grade inflammation
and metabolic health.
Delgado I(1), Huet L(1), Dexpert S(1), Beau C(2), Forestier D(2), Ledaguenel
P(2), Aubert A(1), Sauvant J(1), Aouizerate B(3), Magne E(2), Capuron L(4).
Author information:
(1)INRA, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076
Bordeaux, France; University of Bordeaux, Nutrition and Integrative Neurobiology
(NutriNeuro), UMR 1286, 33076 Bordeaux, France.
(2)Service de Chirurgie Digestive et Pariétale, Clinique Tivoli, 33000 Bordeaux,
and clinique Jean Villar, 33520 Bruges, France.
(3)INRA, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076
Bordeaux, France; University of Bordeaux, Nutrition and Integrative Neurobiology
(NutriNeuro), UMR 1286, 33076 Bordeaux, France; CH Charles Perrens, Pôle de
Psychiatrie Générale et Universitaire, Centre de référence régional des
pathologies anxieuses et dépressives, Bordeaux, France.
(4)INRA, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076
Bordeaux, France; University of Bordeaux, Nutrition and Integrative Neurobiology
(NutriNeuro), UMR 1286, 33076 Bordeaux, France. Electronic address:
.
BACKGROUND: Recent reports suggest that the risk of depressive symptoms in
obesity is potentiated in subjects presenting a metabolically unhealthy
phenotype. Inflammation is often considered a defining criteria of metabolic
health. However, this factor may drive the association of metabolic health with
depressive symptoms given its well-known role in the pathophysiology of
depression. This study aimed at determining the relative contribution of
inflammation and metabolic abnormalities to depressive symptoms in obesity.
METHODS: One-hundred severely obese adults (BMI ≥ 35-40 kg/m2) and 25 non-obese
control individuals (BMI