Debugging the gut-brain axis in depression
Cell Host & Microbe. 2022-03-01; 30(3): 281-283
DOI: 10.1016/j.chom.2022.02.007
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1. Cell Host Microbe. 2022 Mar 9;30(3):281-283. doi: 10.1016/j.chom.2022.02.007.
Debugging the gut-brain axis in depression.
Gheorghe CE(1), Cryan JF(2), Clarke G(3).
Author information:
(1)APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of
Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland;
Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
(2)APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of
Anatomy and Neuroscience, University College Cork, Cork, Ireland.
(3)APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of
Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland;
INFANT Research Centre, University College Cork, Cork, Ireland. Electronic
address: .
Comment on
Cell Host Microbe. 2022 Mar 9;30(3):329-339.e5.
In this issue of Cell Host & Microbe, Li et al. take a step toward a better
understanding of the microbiome-gut-brain axis in mental health. They report
gastrointestinal testosterone degradation by a specific bacterial strain as a
potential mechanism impacting symptom expression in males with depression.
Copyright © 2022 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.chom.2022.02.007
PMID: 35271799 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of interests G.C. has received
honoraria from Janssen, Probi, and Apsen as an invited speaker; is in receipt of
research funding from Pharmavite, Fonterra, Nestle, and Reckitt; and is a paid
consultant for Yakult, Zentiva, and Heel Pharmaceuticals. J.F.C. has been an
invited speaker at conferences organized by Mead Johnson, Alkermes, Janssen,
Ordesa, and Yakult and has received research funding from Mead Johnson, Cremo,
Nutricia, Pharmavite, Dupont, and 4D Pharma. The content of this preview was
neither influenced nor constrained by this support.