Dairy fat blend improves brain DHA and neuroplasticity and regulates corticosterone in mice
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2016-06-01; 109: 29-38
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1. Prostaglandins Leukot Essent Fatty Acids. 2016 Jun;109:29-38. doi:
10.1016/j.plefa.2016.03.013. Epub 2016 Apr 20.
Dairy fat blend improves brain DHA and neuroplasticity and regulates
corticosterone in mice.
Dinel AL(1), Rey C(2), Bonhomme C(3), Le Ruyet P(4), Joffre C(1), Layé S(1).
(1)Nutrition et Neurobiologie Intégrée, INRA UMR 1286, 33076 Bordeaux, France;
University of Bordeaux, Bordeaux, France.
(2)Nutrition et Neurobiologie Intégrée, INRA UMR 1286, 33076 Bordeaux, France;
University of Bordeaux, Bordeaux, France; ITERG, Institut des Corps Gras, 33600
(3)Lactalis Nutrition Europe, Torce F-35370, France.
(4)Lactalis, R&D, Retiers F-35240, France.
Mimicking the breast milk lipid composition appears to be necessary for infant
formula to cover the brain’s needs in n-3 PUFA. In this study, we evaluated the
impact of partial replacement of vegetable oil (VL) in infant formula by dairy
fat (DL) on docosahexaenoic acid (DHA) brain level, neuroplasticity and
corticosterone in mice. Mice were fed with balanced VL or balanced DL diets
enriched or not in DHA and arachidonic acid (ARA) from the first day of
gestation. Brain DHA level, microglia number, neurogenesis, corticosterone and
glucocorticoid receptor expression were measured in the offsprings. DL diet
increased DHA and neuroplasticity in the brain of mice at postnatal day (PND) 14
and at adulthood compared to VL. At PND14, ARA and DHA supplementation increased
DHA in VL but not in DL mice brain. Importantly, DHA and ARA supplementation
further improved neurogenesis and decreased corticosterone level in DL mice at
adulthood. In conclusion, dairy lipids improve brain DHA level and
Copyright © 2016 Elsevier Ltd. All rights reserved.
PMID: 27269711 [Indexed for MEDLINE]