Corticosteroid binding globulin: a new target for cortisol-driven obesity.
Molecular Endocrinology. 2004-07-01; 18(7): 1687-1696
DOI: 10.1210/me.2004-0005
Read on PubMed
1. Mol Endocrinol. 2004 Jul;18(7):1687-96. Epub 2004 Apr 15.
Corticosteroid binding globulin: a new target for cortisol-driven obesity.
Ousova O(1), Guyonnet-Duperat V, Iannuccelli N, Bidanel JP, Milan D, Genêt C,
Llamas B, Yerle M, Gellin J, Chardon P, Emptoz-Bonneton A, Pugeat M, Mormède P,
Moisan MP.
Author information:
(1)Institut National de la Recherche Agronomique, Unité Mixte de Recherche
1243-Institut National de la Santé et de la Recherche Médicale Unité 471,
Université Victor Segalen Bordeaux 2, Institut François Magendie, 33077 Bordeaux,
France.
We present data suggesting that corticosteroid-binding globulin (CBG) may be the
causal gene of a previously identified quantitative trait locus (QTL) associated
with cortisol levels, fat, and muscle content in a pig intercross. Because Cbg in
human and mouse maps in the region orthologous to the pig region containing this
QTL, we considered Cbg as an interesting positional candidate gene because CBG
plays a major role in cortisol bioavailability. Firstly, we cloned pig Cbg from a
bacterial artificial chromosome library and showed by fluorescent in situ
hybridization and radiation hybrid mapping that it maps on 7q26 at the peak of
the QTL interval. Secondly, we detected in a subset of the pig intercross progeny
a highly significant genetic linkage between CBG plasma binding capacity values
and the chromosome 7 markers flanking the cortisol-associated QTL. In this
population, CBG capacity is correlated positively to fat and negatively to muscle
content. Thirdly, CBG capacity was three times higher in Meishan compared with
Large White parental breeds and a 7-fold difference was found in Cbg mRNA
expression between the two breeds. Overall, the data accumulated in this study
point to Cbg gene as a key regulator of cortisol levels and obesity
susceptibility.
DOI: 10.1210/me.2004-0005
PMID: 15087473 [Indexed for MEDLINE]