Correlated bursts of activity in the neonatal hippocampus in vivo
1. Science. 2002 Jun 14;296(5575):2049-52.
Correlated bursts of activity in the neonatal hippocampus in vivo.
Leinekugel X(1), Khazipov R, Cannon R, Hirase H, Ben-Ari Y, Buzsáki G.
Author information:
(1)INMED, Institut National de la Santé et de la Recherche Médicale (INSERM) U29,
Avenue de Luminy, Boite Postale 13, 13273 Marseille Cedex 09, France.
The behavior of immature cortical networks in vivo remains largely unknown. Using
multisite extracellular and patch-clamp recordings, we observed recurrent bursts
of synchronized neuronal activity lasting 0.5 to 3 seconds that occurred
spontaneously in the hippocampus of freely moving and anesthetized rat pups. The
influence of slow rhythms (0.33 and 0.1 hertz) and the contribution of both
gamma-aminobutyric acid A-mediated and glutamate receptor-mediated synaptic
signals in the generation of hippocampal bursts was reminiscent of giant
depolarizing potentials observed in vitro. This earliest pattern, which
diversifies during the second postnatal week, could provide correlated activity
for immature neurons and may underlie activity-dependent maturation of the
hippocampal network.
DOI: 10.1126/science.1071111
PMID: 12065842 [Indexed for MEDLINE]