Controlling complexity: the clinical relevance of mouse complex genetics
Eur J Hum Genet. 2013-05-01; 21(11): 1191-1196
DOI: 10.1038/EJHG.2013.79
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Schughart K(1), Libert C; SYSGENET consortium, Kas MJ.
Collaborators: Andreux P, Aransay AM, Auwerx J, Balling R, Banerjee S, Bezerianos
A, Bragonzi AD, Brockmann GA, Brown S, Campbell-Tofte J, Cendelin J,
Chatziioannou A, Chen D, Crusio W, Dimitrakopoulou K, Falcon JM, Forejt J,
Franken P, Fröhlich LF, Herault Y, Hovatta I, Iraqi FA, Jansen RC, Kaczmarek L,
Kas M, Knapska E, Koks S, Kolisis F, Korostynski M, Lammert F, Lehrach H,
Lengeling A, Libert C, Montagutelli X, Morahan G, Mott R, Panthier JJ, Przewlocki
R, Ranki A, Santos J, Severcan F, Schalkwyk L, Schughart K, Smit AB, Terasmaa A,
Vasar E, Zatloukal K.
Author information:
(1)1] Department of Infection Genetics, Helmholtz Centre for Infection Research,
38124 Braunschweig, Germany [2] University of Veterinary Medicine Hannover,
Germany [3] University of Tennessee Health Science Center, Memphis, TN, USA.
Experimental animal models are essential to obtain basic knowledge of the
underlying biological mechanisms in human diseases. Here, we review major
contributions to biomedical research and discoveries that were obtained in the
mouse model by using forward genetics approaches and that provided key insights
into the biology of human diseases and paved the way for the development of novel
therapeutic approaches.