Complications and adverse effects of deep brain stimulation in Parkinson’s patients

Dominique Guehl, Francois Tison, Emmanuel Cuny, Abdelhamid Benazzouz, Alain Rougier, Bernard Bioulac, Pierre Burbaud
Expert Review of Neurotherapeutics. 2003-11-01; 3(6): 811-819
DOI: 10.1586/14737175.3.6.811

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1. Expert Rev Neurother. 2003 Nov;3(6):811-9. doi: 10.1586/14737175.3.6.811.

Complications and adverse effects of deep brain stimulation in Parkinson’s

Guehl D(1), Tison F, Cuny E, Benazzouz A, Rougier A, Bioulac B, Burbaud P.

Author information:
(1)Service d’Explorations Fonctionnelles du Systeme Nerveux, CHU Bordeaux,
Hopital du Haut Leveque, 33 600 PESSAC, France.

Deep brain stimulation of subcortical structures, such as the subthalamic
nucleus, internal pallidum or ventral intermediate nucleus of the thalamus, are
currently used for the treatment of advanced Parkinson’s disease with motor
fluctuations or during resistant tremor. This review discusses the various
adverse events occurring with this surgery by focusing on each stage of the
procedure and the various stimulated targets. Intraoperative complications are
rare whichever technique or type of target is used. The most frequent
postoperative side effects are observed during stimulation of the subthalamic
nucleus. It is likely that the small size of the nucleus and the possible
spreading of current to the surrounding functional areas contribute to this
phenomenon. However, these side effects are generally mild and transient
compared with the dramatic improvement in motor symptoms and fluctuations. Deep
brain stimulation of the internal pallidum and thalamus are not effective on all
the motor symptoms in Parkinson’s disease but adverse effects appear less
frequently. Whatever the target, intraoperative complications and secondary side
effects are being reduced by the use of new neuroimaging technology associated
with an accurate intraoperative neurophysiological investigation.

DOI: 10.1586/14737175.3.6.811
PMID: 19810884

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