Competing for memory: hippocampal LTP under regimes of reduced protein synthesis.
Neuron. 2004-12-01; 44(6): 1011-1020
DOI: 10.1016/j.neuron.2004.10.033
Read on PubMed
1. Neuron. 2004 Dec 16;44(6):1011-20.
Competing for memory: hippocampal LTP under regimes of reduced protein synthesis.
Fonseca R(1), Nägerl UV, Morris RG, Bonhoeffer T.
Author information:
(1)Max-Planck Institute of Neurobiology, Am Klopferspitz 18, 82152
München-Martinsried, Germany.
Comment in
Neuron. 2004 Dec 16;44(6):903-4.
The persistence of synaptic potentiation in the hippocampus is known to depend on
transcription and protein synthesis. We report here that, under regimes of
reduced protein synthesis, competition between synapses for the relevant
intracellular proteins can be demonstrated. Under such circumstances, the
induction of additional protein synthesis-dependent long-term potentiation for a
given set of postsynaptic neurons occurs at the expense of the maintenance of
prior potentiation on an independent pathway. This new phenomenon, which we call
“competitive maintenance,” has important functional consequences, and it may be
explained in terms of dynamic interactions between synapses and “plasticity
factors” over extended periods of time.
DOI: 10.1016/j.neuron.2004.10.033
PMID: 15603743 [Indexed for MEDLINE]