Common variants at 12q14 and 12q24 are associated with hippocampal volume
1. Nat Genet. 2012 Apr 15;44(5):545-51. doi: 10.1038/ng.2237.
Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Bis JC(1), DeCarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, Debette S,
Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi SH, Sigurdsson S,
Verhaaren BF, DeStefano AL, Lambert JC, Jack CR Jr, Struchalin M, Stankovich J,
Ibrahim-Verbaas CA, Fleischman D, Zijdenbos A, den Heijer T, Mazoyer B, Coker LH,
Enzinger C, Danoy P, Amin N, Arfanakis K, van Buchem MA, de Bruijn RF, Beiser A,
Dufouil C, Huang J, Cavalieri M, Thomson R, Niessen WJ, Chibnik LB, Gislason GK,
Hofman A, Pikula A, Amouyel P, Freeman KB, Phan TG, Oostra BA, Stein JL, Medland
SE, Vasquez AA, Hibar DP, Wright MJ, Franke B, Martin NG, Thompson PM; Enhancing
Neuro Imaging Genetics through Meta-Analysis Consortium, Nalls MA, Uitterlinden
AG, Au R, Elbaz A, Beare RJ, van Swieten JC, Lopez OL, Harris TB, Chouraki V,
Breteler MM, De Jager PL, Becker JT, Vernooij MW, Knopman D, Fazekas F, Wolf PA,
van der Lugt A, Gudnason V, Longstreth WT Jr, Brown MA, Bennett DA, van Duijn CM,
Mosley TH, Schmidt R, Tzourio C, Launer LJ, Ikram MA, Seshadri S; Cohorts for
Heart and Aging Research in Genomic Epidemiology Consortium.
Collaborators: Stein JL, Medland SE, Arias Vasquez A, Hibar DP, Senstad RE,
Winkler AM, Toro R, Appel K, Bartecek R, Bergmann Ø, Bernard M, Brown AA, Cannon
DM, Chakravarty M, Christoforou A, Domin M, Grimm O, Hollinshead M, Holmes AJ,
Homuth G, Hottenga JJ, Langan C, Lopez LM, Hansell NK, Hwang KS, Kim S, Laje G,
Lee PH, Liu X, Loth E, Lourdusamy A, Maniega SM, Mattingsdal M, Mohnke S, Nho K,
Nugent AC, O’Brien C, Papmeyer M, Pütz B, Ramasamy A, Rasmussen J, Rijpkema M,
Risacher SL, Roddey JC, Rose EJ, Ryten M, Shen L, Sprooten E, Strengman E, Teumer
A, Trabzuni D, Turner J, van Eijk K, van Erp TG, van Tol MJ, Wittfeld K, Wolf C,
Woudstra S, Aleman A, Alhusaini S, Almasy L, Binder EB, Brohawn DG, Cantor RM,
Carless MA, Corvin A, Czisch M, Curran JE, Davies G, de Almeida MA, Delanty N,
Depondt C, Duggirala R, Dyer TD, Erk S, Fagerness J, Fox PT, Freimer NB, Gill M,
Göring HH, Hagler DJ, Hoehn D, Holsboer F, Hoogman M, Hosten N, Jahanshad N,
Johnson MP, Kasperaviciute D, Kent JW Jr, Kochunov P, Lancaster JL, Lawrie SM,
Liewald DC, Mandl R, Matarin M, Mattheisen M, Meisenzahl E, Melle I, Moses EK,
Mühleisen TW, Nauck M, Nöthen MM, Olvera RL, Pandolfo M, Pike GB, Puls R,
Reinvang I, Rentería ME, Rietschel M, Roffman JL, Royle NA, Rujescu D, Savitz J,
Schnack HG, Schnell K, Seiferth N, Smith C, Steen VM, Valdés Hernández MC, Van
den Heuvel M, van der Wee NJ, Van Haren NE, Veltman JA, Völzke H, Walker R,
Westlye LT, Whelan CD, Agartz I, Boomsma DI, Cavalleri GL, Dale AM, Djurovic S,
Drevets WC, Hagoort P, Hall J, Heinz A, Jack CR Jr, Foroud TM, Le Hellard S,
Macciardi F, Montgomery GW, Poline JB, Porteous DJ, Sisodiya SM, Starr JM,
Sussmann J, Toga AW, Veltman DJ, Walter H, Weiner MW, Andreassen OA, Apostolova
LG, Bastin ME, Blangero J, Brunner HG, Buckner RL, Cichon S, Coppola G, de
Zubicaray GI, Deary IJ, Donohoe G, de Geus EJ, Espeseth T, Fernández G, Glahn DC,
Grabe HJ, Hardy J, Hulshoff Pol HE, Jenkinson M, Kahn RS, McDonald C, McIntosh
AM, McMahon FJ, McMahon KL, Meyer-Lindenberg A, Morris DW, Müller-Myhsok B,
Nichols TE, Ophoff RA, Paus T, Pausova Z, Penninx BW, Potkin SG, Sämann PG,
Saykin AJ, Schumann G, Smoller JW, Wardlaw JM, Weale ME, Martin NG, Franke B,
Wright MJ, Thompson PM.
Author information:
(1)Cardiovascular Health Research Unit, Department of Medicine, University of
Washington, Seattle, Washington, USA.
Aging is associated with reductions in hippocampal volume that are accelerated by
Alzheimer’s disease and vascular risk factors. Our genome-wide association study
(GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with
P values of