Cognitive impairment in multiple system atrophy: a position statement by the Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study group.

Iva Stankovic, Florian Krismer, Aleksandar Jesic, Angelo Antonini, Thomas Benke, Richard G. Brown, David J. Burn, Janice L. Holton, Horacio Kaufmann, Vladimir S. Kostic, Helen Ling, Wassilios G. Meissner, Werner Poewe, Marija Semnic, Klaus Seppi, Atsushi Takeda, Daniel Weintraub, Gregor K. Wenning,
Mov Disord.. 2014-04-18; 29(7): 857-867
DOI: 10.1002/mds.25880

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1. Mov Disord. 2014 Jun;29(7):857-67. doi: 10.1002/mds.25880. Epub 2014 Apr 18.

Cognitive impairment in multiple system atrophy: a position statement by the
Neuropsychology Task Force of the MDS Multiple System Atrophy (MODIMSA) study
group.

Stankovic I(1), Krismer F, Jesic A, Antonini A, Benke T, Brown RG, Burn DJ,
Holton JL, Kaufmann H, Kostic VS, Ling H, Meissner WG, Poewe W, Semnic M, Seppi
K, Takeda A, Weintraub D, Wenning GK; Movement Disorders Society MSA (MODIMSA)
Study Group.

Author information:
(1)Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of
Belgrade, Belgrade, Serbia.

Consensus diagnostic criteria for multiple system atrophy consider dementia as a
nonsupporting feature, despite emerging evidence demonstrating that cognitive
impairments are an integral part of the disease. Cognitive disturbances in
multiple system atrophy occur across a wide spectrum from mild single domain
deficits to impairments in multiple domains and even to frank dementia in some
cases. Frontal-executive dysfunction is the most common presentation, while
memory and visuospatial functions also may be impaired. Imaging and
neuropathological findings support the concept that cognitive impairments in MSA
originate from striatofrontal deafferentation, with additional contributions from
intrinsic cortical degeneration and cerebellar pathology. Based on a
comprehensive evidence-based review, the authors propose future avenues of
research that ultimately may lead to diagnostic criteria for cognitive impairment
and dementia associated with multiple system atrophy.

© 2014 International Parkinson and Movement Disorder Society.

DOI: 10.1002/mds.25880
PMCID: PMC4175376
PMID: 24753321 [Indexed for MEDLINE]

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