Cognitive impairment in a population-based study of patients with multiple sclerosis: Differences between late relapsing-remitting, secondary progressive and primary progressive multiple sclerosis
Eur J Neurol. 2015-04-22; 23(2): 282-289
DOI: 10.1111/ene.12715
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1. Eur J Neurol. 2016 Feb;23(2):282-9. doi: 10.1111/ene.12715. Epub 2015 Apr 22.
Cognitive impairment in a population-based study of patients with multiple
sclerosis: differences between late relapsing-remitting, secondary progressive
and primary progressive multiple sclerosis.
Planche V(1), Gibelin M(2), Cregut D(3), Pereira B(4), Clavelou P(1)(2)(5)(6).
Author information:
(1)Service de Neurologie, CHU Gabriel Montpied, Clermont-Ferrand, France.
(2)Réseau NeuroSEP Auvergne, Beaumont, France.
(3)Centre Mémoire de Ressources et de Recherche, CHU Gabriel Montpied,
Clermont-Ferrand, France.
(4)Délégation à la recherche clinique et à l’innovation, CHU Gabriel Montpied,
Clermont-Ferrand, France.
(5)Neuro-Dol, Université d’Auvergne, Clermont-Ferrand, France.
(6)Inserm U1107, Clermont-Ferrand, France.
Comment in
Eur J Neurol. 2016 Feb;23(2):225-6.
BACKGROUND AND PURPOSE: Few studies have investigated the differences in
cognitive skills between the three subtypes of multiple sclerosis (MS) and they
confounded the course of the disease with the duration of the disease and the
physical disability. Moreover, they were not population based.
METHODS: This was a retrospective analysis of cognitive testing from the database
of a French programme for MS care. The pattern and the frequency of cognitive
impairment in secondary progressive (SP), primary progressive (PP) and late
relapsing-remitting (LRR, disease duration of more than 10 years) MS were
compared.
RESULTS: A total of 101 patients with MS (41 LRRMS, 37 SPMS, 23 PPMS) were
included. 63.0% had a significant cognitive impairment. After controlling for
age, sex, Expanded Disability Status Scale, disease duration and education level,
patients with SPMS were at least 2-fold more frequently impaired than patients
with LLRMS in information processing speed (P = 0.005), executive functions
(P = 0.04), verbal fluency (P = 0.02), verbal episodic memory (P = 0.04), working
memory (P = 0.02) and visuospatial construction (P = 0.01). The number of
patients with at least one or two deficient cognitive domain(s) was higher in the
SPMS group than in the LRRMS group (P = 0.002 and P