Changes in meibomian fatty acids and clinical signs in patients with meibomian gland dysfunction after minocycline treatment
British Journal of Ophthalmology. 2008-05-29; 92(6): 819-822
DOI: 10.1136/bjo.2007.133900
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1. Br J Ophthalmol. 2008 Jun;92(6):819-22. doi: 10.1136/bjo.2007.133900. Epub 2008
May 29.
Changes in meibomian fatty acids and clinical signs in patients with meibomian
gland dysfunction after minocycline treatment.
Souchier M(1), Joffre C, Grégoire S, Bretillon L, Muselier A, Acar N, Beynat J,
Bron A, D’Athis P, Creuzot-Garcher C.
Author information:
(1)Department of Ophthalmology, University Hospital, Dijon, France.
AIMS: To assess the changes in ocular surface abnormalities and meibomian fatty
acid composition in patients suffering from meibomian gland dysfunction (MGD)
after treatment with oral minocycline associated with lid hygiene versus lid
hygiene only.
METHODS: We evaluated the break-up time, corneal staining and quality of
meibomian excreta, and collected meibomian oil in 20 individuals suffering from
MGD before and after 8 weeks of minocycline associated with lid hygiene (n = 10)
or lid hygiene only (n = 10). Meibomian fatty acids were directly transmethylated
and analysed by gas chromatography (GC) and GC mass spectrometry.
RESULTS: The meibomian fatty acid composition was slightly modified after 8 weeks
in both groups. The decrease in a branched-chain fatty acid (isoC20) was greater
after minocycline treatment than after lid hygiene only (-65% and -25%,
respectively; p