Cerebral alterations in West African HIV and non-HIV adults aged ≥50: An MRI study.
International Journal of Infectious Diseases. 2021-02-01; 103: 457-463
DOI: 10.1016/j.ijid.2020.12.016
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Bernard C(1), Dilharreguy B(2), Font H(3), Diop AN(4), Tine JM(5), Diakhate IC(6), Seydi M(5), Dartigues JF(3), Dabis F(3), Catheline G(2), Bonnet F(7).
Author information:
(1)INSERM, Centre INSERM U1219-Epidémiologie-Biostatistique, University of
Bordeaux, F-3300 Bordeaux, France; University of Bordeaux, School of Public
Health (ISPED), F-33000 Bordeaux, France. Electronic address:
.
(2)UMR 5287 CNRS, Université de Bordeaux, EPHE PSL Research University, F-33000
Bordeaux, France.
(3)INSERM, Centre INSERM U1219-Epidémiologie-Biostatistique, University of
Bordeaux, F-3300 Bordeaux, France; University of Bordeaux, School of Public
Health (ISPED), F-33000 Bordeaux, France.
(4)UFR 2S/Université Gaston Berger de St Louis, Saint-Louis, Senegal.
(5)Service de maladies infectieuses et tropicales, CRCF, CHNU de Fann, Dakar,
Senegal.
(6)Service de radiologie, hôpital Principal, Dakar, Senegal.
(7)INSERM, Centre INSERM U1219-Epidémiologie-Biostatistique, University of
Bordeaux, F-3300 Bordeaux, France; University of Bordeaux, School of Public
Health (ISPED), F-33000 Bordeaux, France; CHU de Bordeaux, Hôpital Saint-André,
service de Médecine interne et Maladies Infectieuses, F-33000 Bordeaux, France.
OBJECTIVES: To cross-sectionally describe brain alterations in PLHIV aged above
50 years old, receiving antiretroviral treatment (ART) and living in Senegal
compared to HIV-negative subjects.
METHODS: Twenty PLHIV and 26 HIV-negative subjects with comparable
socio-demographic and clinical characteristics underwent an MRI exam (3D-T1 and
FLAIR sequences). Global atrophy and White Matter Hyperintensities (WMH) were
evaluated. After assessing the feasibility and acceptability of MRI scans in this
population, we described atrophy and WHM prevalence and associated factors using
logistic regressions.
RESULTS: Overall, 43.5% of the study sample were aged ≥60 years, 58.7% were
women, and 28.3% had hypertension. The overall prevalence of atrophy and WMH was
19.6% [95% CI: 8.1-31.1] and 30.4% [95% CI: 17.1-43.7]. HIV status had no
significant effect on atrophy or WMH. Unemployment and hypertension were
significantly associated with atrophy, whereas women were less likely to present
atrophy. Aged ≥60 years was the only factor associated with WMH.
CONCLUSIONS: A high prevalence of atrophy and WMH was observed in West African
adults aged over 50 years without a clear HIV impact. As brain MRI studies are
critical to better understand cognitive and emotional outcomes, we encourage
those studies in older PLHIV in West Africa.
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.ijid.2020.12.016
PMCID: PMC8620126
PMID: 33310027 [Indexed for MEDLINE]