Cavitary lesions in multiple sclerosis: Multicenter study on twenty patients

A. Corlobé, D. Renard, C. Goizet, E. Berger, L. Rumbach, A. Robinson, D. Dupuy, E. Touzé, H. Zéphir, P. Vermersch, B. Brochet, G. Edan, V. Deburghgraeve, A. Créange, G. Castelnovo, M. Cohen, C. Lebrun-Frenay, O. Boespflug-Tanguy, P. Labauge
Revue Neurologique. 2013-12-01; 169(12): 965-969
DOI: 10.1016/J.NEUROL.2013.02.010

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1. Rev Neurol (Paris). 2013 Dec;169(12):965-9. doi: 10.1016/j.neurol.2013.02.010.
Epub 2013 Oct 17.

[Cavitary lesions in multiple sclerosis: multicenter study on twenty patients].

[Article in French]

Corlobé A(1), Renard D, Goizet C, Berger E, Rumbach L, Robinson A, Dupuy D, Touzé
E, Zéphir H, Vermersch P, Brochet B, Edan G, Deburghgraeve V, Créange A,
Castelnovo G, Cohen M, Lebrun-Frenay C, Boespflug-Tanguy O, Labauge P.

Author information:
(1)Service de neurologie, hôpital Gui-de-Chauliac, 80, avenue Augustin-Fliche,
34295 Montpellier cedex 5, France.

INTRODUCTION: Cavitary white matter changes are mainly described in
leukodystrophies and especially in vanishing white matter disease. Large cavitary
lesions are not typical for multiple sclerosis (MS).
METHODS: We studied MS patients with large cavitary brain lesions. Patient
characteristics, disease onset/duration/subtype, expanded disability status scale
(EDSS), mini mental state (MMS), vanishing white matter disease genetic analysis,
and MRI characteristics of the cavitary lesions were analyzed.
RESULTS: Twenty patients were analyzed (6 men and 14 women). Mean age at disease
onset was 37.6 (range 17-58). Mean disease duration was 10 years (range 2-20).
Five patients had initial relapsing-remitting MS and nine patients had
primary-progressive MS. Mean EDSS was 5.5 (range 2-8). Mean MMS was 20/30.
Vanishing white matter disease genetic analysis was performed and negative in
seven patients. Inferior corpus callosum lesions were seen in all patients with
available sagittal FLAIR sequences. Cavitary lesions were strictly
supratentorial, and located inside the diffuse leukoencephalopathy, with often a
posterior predominance.
CONCLUSION: MS patients with large cavitary lesions seem to represent a MS
subgroup, predominantly women, with relatively late disease onset, predominantly
primary-progressive type, relatively high EDSS scores, and severe cognitive

Copyright © 2013 Elsevier Masson SAS. All rights reserved.

DOI: 10.1016/j.neurol.2013.02.010
PMID: 24139243 [Indexed for MEDLINE]

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