Blood polyunsaturated omega-3 fatty acids, brain atrophy, cognitive decline, and dementia risk.

Aline Thomas, Marion Baillet, Cécile Proust‐Lima, Catherine Féart, Alexandra Foubert‐Samier, Catherine Helmer, Gwénaëlle Catheline, Cécilia Samieri
Alzheimer's & Dementia. 2020-10-08; :
DOI: 10.1002/alz.12195

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Thomas A(1), Baillet M(1), Proust-Lima C(1), Féart C(1), Foubert-Samier A(1)(2), Helmer C(1), Catheline G(3)(4), Samieri C(1).

Author information:
(1)INSERM, BPH, U1219, Univ. Bordeaux, Bordeaux, F-33000, France.
(2)Institut des Maladies Neurodégénératives, Bordeaux Univ. Hospital, Bordeaux, F-33000, France.
(3)CNRS, INCIA, UMR5287, Univ. Bordeaux, Bordeaux, F-33000, France.
(4)Laboratoire Neuroimagerie et vie quotidienne, EPHE-PSL, Bordeaux, F-33000, France.

INTRODUCTION: We searched for consistent associations of an omega-3 index in plasma (sum of eicosapentaenoic acid EPA and docosahexaenoic acid DHA) with several dementia-related outcomes in a large cohort of older adults.

METHODS: We included 1279 participants from the Three-City study, non-demented at the time of blood measurements at baseline, with face-to-face neuropsychological assessment and systematic detection of incident dementia over a 17-year follow-up. An ancillary study included 467 participants with up to three repeated brain imaging exams over 10 years.

RESULTS: In multivariable models, higher levels of plasma EPA+DHA were consistently associated with a lower risk of dementia (hazard ratio for 1 standard deviation = 0.87 [95% confidence interval, 0.76-0.98]), and a lower decline in global cognition (P = .04 for change over time), memory (P = .06), and medial temporal lobe volume (P = .02).

DISCUSSION: This prospective study provides compelling evidence for a relationship between long-chain omega-3 fatty acids levels and lower risks for dementia and related outcomes.

© 2020 the Alzheimer’s Association.


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