Bimodal control of stimulated food intake by the endocannabinoid system.
Nat Neurosci. 2010-02-07; 13(3): 281-283
DOI: 10.1038/nn.2494
Read on PubMed
1. Nat Neurosci. 2010 Mar;13(3):281-3. doi: 10.1038/nn.2494. Epub 2010 Feb 7.
Bimodal control of stimulated food intake by the endocannabinoid system.
Bellocchio L(1), Lafenêtre P, Cannich A, Cota D, Puente N, Grandes P, Chaouloff
F, Piazza PV, Marsicano G.
Author information:
(1)INSERM U862, NeuroCentre Magendie, Endocannabinoids and Neuroadaptation,
Bordeaux, France.
Activation of cannabinoid type-1 receptors (CB(1)) is universally recognized as a
powerful endogenous orexigenic signal, but the detailed underlying neuronal
mechanisms are not fully understood. Using combined genetic and pharmacological
approaches in mice, we found that ventral striatal CB(1) receptors exerted a
hypophagic action through inhibition of GABAergic transmission. Conversely, brain
CB(1) receptors modulating excitatory transmission mediated the well-known
orexigenic effects of cannabinoids.
DOI: 10.1038/nn.2494
PMID: 20139974 [Indexed for MEDLINE]