Behavioral effects of chronic stress in the Fmr1 mouse model for fragile X syndrome.
Behavioural Brain Research. 2017-03-01; 320: 128-135
DOI: 10.1016/j.bbr.2016.11.051
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Lemaire-Mayo V(1), Subashi E(1), Henkous N(1), Beracochea D(1), Pietropaolo S(2).
Author information:
(1)Univ. Bordeaux, INCIA, Bat B2, Allée Geoffroy St. Hilaire, CS 50023, 33615,
Pessac Cedex, France; CNRS, INCIA, UMR 5287, Bat B2, Allée Geoffroy St. Hilaire,
CS 50023, 33615, Pessac Cedex, France.
(2)Univ. Bordeaux, INCIA, Bat B2, Allée Geoffroy St. Hilaire, CS 50023, 33615,
Pessac Cedex, France; CNRS, INCIA, UMR 5287, Bat B2, Allée Geoffroy St. Hilaire,
CS 50023, 33615, Pessac Cedex, France. Electronic address:
.
Fragile X Syndrome (FXS) is a pervasive developmental disorder due to a mutation
in the FMR1 X-linked gene. Despite its clear genetic cause, the expression of
FXS symptoms is known to be modulated by environmental factors, including
stress. Furthermore, several studies have shown disturbances in stress
regulatory systems in FXS patients and Fmr1 mice. These studies have mostly
focused on the hormonal responses to stress, using the acute exposure to a
single type of stressor. Hence, little is known about the behavioral effects of
stress in FXS, and the importance of the nature of the stressing procedure,
especially in the context of a repeated exposure that more closely resembles
real life conditions. Here we evaluated the effects of chronic exposure to
different types of stress (i.e., either repeated restraint or unpredictable
stress) on the behavioral phenotype of adult Fmr1 mice. Our results demonstrated
that chronic stress induced deficits in social interaction and working memory
only in WT mice and the impact of stress depended on the type of stressors and
the specific behavior tested. Our data suggest that the behavioral sensitivity
to stress is dramatically reduced in FXS, opening new views on the impact of
gene-environment interactions in this pathology.
Copyright © 2016. Published by Elsevier B.V.