Associations of glucocorticoid receptor and corticosteroid-binding globulin gene polymorphisms on fat mass and fat mass distribution in prepubertal obese children.
J Physiol Biochem. 2012-05-12; 68(4): 645-650
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Barat P(1), Corcuff JB, Tauber M, Moisan MP.
(1)Université Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286 Bordeaux,
Previous studies conducted in adult obese patients have shown that glucocorticoid
receptor and corticosteroid-binding globulin gene polymorphisms influence
cortisol-driven obesity and metabolic parameters. We investigated the impact of
these polymorphisms in prepubertal obese children that were thoroughly examined
for hypothalamic-pituitary-adrenal axis activity and for metabolic and obesity
parameters. Obese children carrier of the allele G of the BclI polymorphism
within glucocorticoid receptor gene tend to present a higher percentage of fat
mass as well as a decreased cortisol suppression after low-dose dexamethasone as
found in adult studies. Additionally, these allele G carriers show a strong
correlation between truncal fat mass distribution and cortisol response to a
standardized lunch, whereas this correlation is weak in allele C carriers. No
differences were found for obesity or metabolic parameters between genotypes at
the corticosteroid-binding globulin locus. However, allele 90 carriers present
increased 24-h free urinary cortisol. Overall, this study provides new data
showing the influence of glucocorticoid receptor and corticosteroid-binding
globulin genes in obesity and/or cortisol action in prepubertal obese children.
PMID: 22576823 [Indexed for MEDLINE]