Aprotinin confers neuroprotection by reducing apoptotic cell death

Yusuke Iwata, Olivier Nicole, Toru Okamura, David Zurakowski, Richard A Jonas
Asian Cardiovasc Thorac Ann. 2010-04-01; 18(2): 170-173
DOI: 10.1177/0218492310362120

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1. Asian Cardiovasc Thorac Ann. 2010 Feb;18(2):170-3. doi: 10.1177/0218492310362120.

Aprotinin confers neuroprotection by reducing apoptotic cell death.

Iwata Y(1), Nicole O, Okamura T, Zurakowski D, Jonas RA.

Author information:
(1)Children’s National Medical Center, 111 Michigan Avenue NW, Washington, DC
20010, USA.

Aprotinin has been used in pediatric cardiac surgery for its antiinflammatory and
hemostatic benefits. We have reported that aprotinin has a direct cellular
neuroprotective effect through reduction of excitotoxicity. The purpose of this
study was to investigate whether aprotinin is neuroprotective against apoptotic
cell death. Near-pure neuronal cultures containing


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