Apolipoprotein e genotype is related to progression of white matter lesion load

O. Godin, C. Tzourio, P. Maillard, A. Alperovitch, B. Mazoyer, C. Dufouil
Stroke. 2009-07-30; 40(10): 3186-3190
DOI: 10.1161/STROKEAHA.109.555839

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1. Stroke. 2009 Oct;40(10):3186-90. doi: 10.1161/STROKEAHA.109.555839. Epub 2009 Jul

Apolipoprotein E genotype is related to progression of white matter lesion load.

Godin O(1), Tzourio C, Maillard P, Alpérovitch A, Mazoyer B, Dufouil C.

Author information:
(1)Inserm Unit 708 Neuroepidemiology, Hôpital la Salpétrière, Paris, France.

BACKGROUND AND PURPOSE: The relationship between white matter lesions (WMLs) and
the apolipoprotein E genotype has been controversial from cross-sectional studies
and no longitudinal finding has been reported. We investigated whether the
apolipoprotein E genotype influences baseline and evolution over 4-year follow-up
of WML volumes in a population-based sample of 1779 nondemented subjects aged 65
to 80 years old at enrollment.
METHODS: The sample consisted of 3C-Dijon study participants who had 2 cerebral
MRIs, at entry and at 4-year follow-up. WML volumes were estimated using a fully
automatic procedure. We performed analysis of covariance to evaluate the
relationship between apolipoprotein E genotype and WML load and progression.
RESULTS: Multivariable analyses showed that epsilon4epsilon4 individuals had both
significantly higher WML volume at baseline and higher WML increase over 4-year
follow-up than noncarriers and heterozygous of the epsilon4 allele for
apolipoprotein E genotype.
CONCLUSION: These findings suggest it might be important to take into account WML
severity when assessing the relationship between apolipoprotein E and dementia.

DOI: 10.1161/STROKEAHA.109.555839
PMID: 19644067 [Indexed for MEDLINE]

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