Amygdala Inhibitory Circuits and the Control of Fear Memory
Neuron. 2009-06-01; 62(6): 757-771
Read on PubMed
1. Neuron. 2009 Jun 25;62(6):757-71. doi: 10.1016/j.neuron.2009.05.026.
Amygdala inhibitory circuits and the control of fear memory.
Ehrlich I(1), Humeau Y, Grenier F, Ciocchi S, Herry C, Lüthi A.
(1)Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
Classical fear conditioning is a powerful behavioral paradigm that is widely used
to study the neuronal substrates of learning and memory. Previous studies have
clearly identified the amygdala as a key brain structure for acquisition and
storage of fear memory traces. Whereas the majority of this work has focused on
principal cells and glutamatergic transmission and its plasticity, recent studies
have started to shed light on the intricate roles of local inhibitory circuits.
Here, we review current understanding and emerging concepts of how local
inhibitory circuits in the amygdala control the acquisition, expression, and
extinction of conditioned fear at different levels.
PMID: 19555645 [Indexed for MEDLINE]