Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type.
Nat Commun. 2013-07-10; 4(1):
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1. Nat Commun. 2013;4:2125. doi: 10.1038/ncomms3125.
Amplification of progenitors in the mammalian telencephalon includes a new radial
glial cell type.
Pilz GA(1), Shitamukai A, Reillo I, Pacary E, Schwausch J, Stahl R, Ninkovic J,
Snippert HJ, Clevers H, Godinho L, Guillemot F, Borrell V, Matsuzaki F, Götz M.
(1)Institute of Stem Cell Research, Helmholtz Center Munich, Ingolstädter
Landstr. 1, Neuherberg, 85764 Munich, Germany.
The mechanisms governing the expansion of neuron number in specific brain regions
are still poorly understood. Enlarged neuron numbers in different species are
often anticipated by increased numbers of progenitors dividing in the
subventricular zone. Here we present live imaging analysis of radial glial cells
and their progeny in the ventral telencephalon, the region with the largest
subventricular zone in the murine brain during neurogenesis. We observe lineage
amplification by a new type of progenitor, including bipolar radial glial cells
dividing at subapical positions and generating further proliferating progeny. The
frequency of this new type of progenitor is increased not only in larger clones
of the mouse lateral ganglionic eminence but also in cerebral cortices of gyrated
species, and upon inducing gyrification in the murine cerebral cortex. This
implies key roles of this new type of radial glia in ontogeny and phylogeny.
PMID: 23839311 [Indexed for MEDLINE]