AMPAR-Dependent Synaptic Plasticity Initiates Cortical Remapping and Adaptive Behaviors during Sensory Experience
Cell Reports. 2020-09-01; 32(9): 108097
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Campelo T(1), Augusto E(1), Chenouard N(1), de Miranda A(1), Kouskoff V(1), Camus C(1), Choquet D(2), Gambino F(3).
(1)University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, 33000 Bordeaux, France.
(2)University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, IINS, UMR 5297, 33000 Bordeaux, France; University of Bordeaux, CNRS, INSERM, Bordeaux Imaging Center, BIC, UMS 3420, US 4, 33000 Bordeaux, France. Electronic
(3)University of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, R 5297, 33000 Bordeaux, France. Electronic address: .
Cortical plasticity improves behaviors and helps recover lost functions after
injury. However, the underlying synaptic mechanisms remain unclear. In mice, we
show that trimming all but one whisker enhances sensory responses from the spared
whisker in the barrel cortex and occludes whisker-mediated synaptic potentiation
(w-Pot) in vivo. In addition, whisker-dependent behaviors that are initially
impaired by single-whisker experience (SWE) rapidly recover when associated
cortical regions remap. Cross-linking the surface GluA2 subunit of AMPA receptors
(AMPARs) suppresses the expression of w-Pot, presumably by blocking AMPAR surface
diffusion, in mice with all whiskers intact, indicating that synaptic
potentiation in vivo requires AMPAR trafficking. We use this approach to
demonstrate that w-Pot is required for SWE-mediated strengthening of synaptic
inputs and initiates the recovery of previously learned skills during the early
phases of SWE. Taken together, our data reveal that w-Pot mediates cortical
remapping and behavioral improvement upon partial sensory deafferentation.
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.