AMPA receptor nanoscale dynamic organization and synaptic plasticities
Current Opinion in Neurobiology. 2020-08-01; 63: 137-145
DOI: 10.1016/j.conb.2020.04.003
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Choquet D(1), Hosy E(2).
Author information:
(1)Interdisciplinary Institute for Neuroscience, University of Bordeaux,
Bordeaux, France; Interdisciplinary Institute for Neuroscience, Centre National
de la Recherche Scientifique (CNRS) UMR 5297, Bordeaux, France; Bordeaux Imaging
Center, CNRS UMS 3420, University of Bordeaux, INSERM US04, Bordeaux, France.
Electronic address: .
(2)Interdisciplinary Institute for Neuroscience, University of Bordeaux,
Bordeaux, France; Interdisciplinary Institute for Neuroscience, Centre National
de la Recherche Scientifique (CNRS) UMR 5297, Bordeaux, France. Electronic
address: .
The emergence of new imaging techniques and molecular tools has refreshed our
understanding of the principles of synaptic transmission and plasticity.
Superresolution imaging and biosensors for measuring enzymatic activities in live
neurons or neurotransmitter levels in the synaptic cleft are giving us an
unprecedented integrated and nanoscale view on synaptic function. Excitatory
synapses are now conceptualized as organized in subdomains, enriched with
specific scaffolding proteins and glutamate receptors, molecularly organized with
respect to the pre-synaptic source of glutamate. This new vision of basic
synaptic transmission changes our understanding of the molecular modifications
which sustain synaptic plasticities. Long-term potentiation can no longer be
explained simply by an increase in receptor content at the synapse. We review
here the latest data on the role of nanoscale and dynamic organization of AMPA
type glutamate receptors on synaptic transmission at both basal state and during
short and long-term plasticities.
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