Altered hemispheric lateralization of white matter pathways in developmental dyslexia: Evidence from spherical deconvolution tractography

Jingjing Zhao, Michel Thiebaut de Schotten, Irene Altarelli, Jessica Dubois, Franck Ramus
Cortex. 2016-03-01; 76: 51-62
DOI: 10.1016/j.cortex.2015.12.004

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1. Cortex. 2016 Mar;76:51-62. doi: 10.1016/j.cortex.2015.12.004. Epub 2016 Jan 14.

Altered hemispheric lateralization of white matter pathways in developmental
dyslexia: Evidence from spherical deconvolution tractography.

Zhao J(1), Thiebaut de Schotten M(2), Altarelli I(3), Dubois J(4), Ramus F(5).

Author information:
(1)School of Psychology, Shaanxi Normal University and Shaanxi Provincial Key
Laboratory of Behavior and Cognitive Neuroscience, Xi’an, China; Laboratoire de
Sciences Cognitives et Psycholinguistique (ENS, EHESS, CNRS), Département
d’Etudes Cognitives, Ecole Normale Supérieure, PSL Research University, Paris
Cedex 05, France. Electronic address: .
(2)Brain Connectivity and Behaviour Group, Brain and Spine Institute (ICM), CNRS
UMR 7225, INSERM-UPMC UMRS 1127, Paris, France.
(3)Laboratoire de Sciences Cognitives et Psycholinguistique (ENS, EHESS, CNRS),
Département d’Etudes Cognitives, Ecole Normale Supérieure, PSL Research
University, Paris Cedex 05, France; FPSE, University of Geneva, Geneva,
Switzerland.
(4)INSERM, U992, CEA/Neurospin, Gif-sur-Yvette, France; University Paris-Sud,
Orsay, France.
(5)Laboratoire de Sciences Cognitives et Psycholinguistique (ENS, EHESS, CNRS),
Département d’Etudes Cognitives, Ecole Normale Supérieure, PSL Research
University, Paris Cedex 05, France. Electronic address: .

This study examines the structural integrity and the hemispheric lateralization
patterns of four major association fiber pathways in a group of French dyslexic
children and age-matched controls (from 9 to 14 years), using high angular
diffusion imaging combined with spherical deconvolution tractography. Compared
with age-matched controls, dyslexic children show increased hindrance-modulated
oriented anisotropy (HMOA) in the right superior longitudinal fasciculus (SLF).
They also show a reduced leftward asymmetry of the inferior fronto-occipital
fasciculus (IFOF) and an increased rightward asymmetry of the second branch of
the SLF (SLF II). The lateralization pattern of IFOF and SLF II also accounts for
individual differences in dyslexic children’s reading abilities. These data
provide evidence for an abnormal lateralization of occipito-frontal and
parieto-frontal pathways in developmental dyslexia.

Copyright © 2016 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.cortex.2015.12.004
PMID: 26859852 [Indexed for MEDLINE]

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