Adult-born dentate neurons are recruited in both spatial memory encoding and retrieval.
Hippocampus. 2015-05-13; 25(11): 1472-1479
DOI: 10.1002/hipo.22468
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1. Hippocampus. 2015 Nov;25(11):1472-9. doi: 10.1002/hipo.22468. Epub 2015 May 13.
Adult-born dentate neurons are recruited in both spatial memory encoding and
retrieval.
Tronel S(1)(2), Charrier V(1)(2), Sage C(1)(2), Maitre M(1)(2), Leste-Lasserre
T(1)(2), Abrous DN(1)(2).
Author information:
(1)Neurocentre MagendiePhysiopathologie De La Plasticité NeuronaleUnité 862,
Institut National De La Santé Et De La Recherche Médicale, Inserm U862,
Bordeaux-F33077, Paris, France.
(2)Université Bordeaux, Bordeaux-F33000, France.
Adult neurogenesis occurs in the dentate gyrus (DG) of the hippocampus, which is
a key structure in learning and memory. Adult-generated granule cells have been
shown to play a role in spatial memory processes such as acquisition or
retrieval, in particular during an immature stage when they exhibit a period of
increased plasticity. Here, we demonstrate that immature and mature neurons born
in the DG of adult rats are similarly activated in spatial memory processes. By
imaging the activation of these two different neuron generations in the same rat
and by using the immediate early gene Zif268, we show that these neurons are
involved in both spatial memory acquisition and retrieval. These results
demonstrate that adult-generated granule cells are involved in memory beyond
their immaturity stage.
© 2015 Wiley Periodicals, Inc.
DOI: 10.1002/hipo.22468
PMID: 25913775 [Indexed for MEDLINE]