Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses.
Neuron. 2008-01-01; 57(1): 121-134
DOI: 10.1016/j.neuron.2007.11.023
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1. Neuron. 2008 Jan 10;57(1):121-34. doi: 10.1016/j.neuron.2007.11.023.
Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at
hippocampal mossy fiber synapses.
Rebola N(1), Lujan R, Cunha RA, Mulle C.
Author information:
(1)Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of
Medicine, University of Coimbra, Coimbra 3004-504, Portugal.
Comment in
Neuron. 2008 Jan 10;57(1):5-7.
The physiological conditions under which adenosine A2A receptors modulate
synaptic transmission are presently unclear. We show that A2A receptors are
localized postsynaptically at synapses between mossy fibers and CA3 pyramidal
cells and are essential for a form of long-term potentiation (LTP) of NMDA-EPSCs
induced by short bursts of mossy fiber stimulation. This LTP spares AMPA-EPSCs
and is likely induced and expressed postsynaptically. It depends on a
postsynaptic Ca2+ rise, on G protein activation, and on Src kinase. In addition
to A2A receptors, LTP of NMDA-EPSCs requires the activation of NMDA and mGluR5
receptors as potential sources of Ca2+ increase. LTP of NMDA-EPSCs displays a
lower threshold for induction as compared with the conventional presynaptic mossy
fiber LTP; however, the two forms of LTP can combine with stronger induction
protocols. Thus, postsynaptic A2A receptors may potentially affect information
processing in CA3 neuronal networks and memory performance.
DOI: 10.1016/j.neuron.2007.11.023
PMID: 18184569 [Indexed for MEDLINE]