Activity/rest cycle and disturbances of structural backbone of cerebral networks in aging.

Marion Baillet, Bixente Dilharreguy, Karine Pérès, Jean-François Dartigues, Willy Mayo, Gwenaëlle Catheline
NeuroImage. 2017-02-01; 146: 814-820
DOI: 10.1016/j.neuroimage.2016.09.051

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1. Neuroimage. 2017 Feb 1;146:814-820. doi: 10.1016/j.neuroimage.2016.09.051. Epub
2016 Sep 21.

Activity/rest cycle and disturbances of structural backbone of cerebral networks
in aging.

Baillet M(1), Dilharreguy B(2), Pérès K(3), Dartigues JF(3), Mayo W(2), Catheline
G(4).

Author information:
(1)Université de Bordeaux, INCIA, UMR 5287 – équipe NeuroImagerie et Cognition
Humaine, F-33000 Bordeaux, France; CNRS, INCIA, UMR 5287 – équipe NeuroImagerie
et Cognition Humaine, F-33000 Bordeaux, France. Electronic address:
.
(2)Université de Bordeaux, INCIA, UMR 5287 – équipe NeuroImagerie et Cognition
Humaine, F-33000 Bordeaux, France; CNRS, INCIA, UMR 5287 – équipe NeuroImagerie
et Cognition Humaine, F-33000 Bordeaux, France.
(3)Université de Bordeaux, ISPED, Centre INSERM U1219 – Bordeaux Population
Health Research Center, F-33000 Bordeaux, France; INSERM, ISPED, Centre INSERM
U1219 – Bordeaux Population Heath Research Center, F-33000 Bordeaux, France.
(4)Université de Bordeaux, INCIA, UMR 5287 – équipe NeuroImagerie et Cognition
Humaine, F-33000 Bordeaux, France; CNRS, INCIA, UMR 5287 – équipe NeuroImagerie
et Cognition Humaine, F-33000 Bordeaux, France; EPHE, PSL Research University,
F-33000 Bordeaux, France.

OBJECTIVE: Although aging is associated with alterations of both activity/rest
cycle and brain structure, few studies have evaluated associations between these
processes. The aim of this study was to examine relationship between
activity/rest cycle quality and brain structural integrity in aging subjects by
exploring both grey and white matter compartments.
MATERIAL AND METHODS: Fifty-eight elderly subjects (76±0.5 years; 41% female)
without dementia, sleep disorders and medications were included in the analysis.
Actigraphy was used to measure parameters of activity/rest cycle (24-h amplitude,
24-h fragmentation and 24-h stability) and sleep (total sleep time and sleep
fragmentation) over a minimal period of 5 days. Whole brain linear regression
analyses were performed on grey matter volumes maps using voxel based morphometry
and on white matter integrity using tract based statistics analyses.
RESULTS: A lower 24-h amplitude and a higher sleep fragmentation were
independently associated with a reduction of white matter integrity in models
including age and gender as covariates. The association between 24-h amplitude
and white matter integrity decreased but remained significant in a model
accounted for sleep fragmentation, indicating a specific effect of 24-h cycle
disturbances. No association with grey matter volumes was observed.
CONCLUSION: In elderly, not only sleep but also 24-h cycle disturbances were
associated with altered structural connectivity. This alteration of structural
backbone networks related to activity/rest cycle disturbances in aging might
constitute a cerebral frailty factor for the development of cognitive impairment.

Copyright © 2016 Elsevier Inc. All rights reserved.

DOI: 10.1016/j.neuroimage.2016.09.051
PMID: 27664829 [Indexed for MEDLINE]

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