A revised limbic system model for memory, emotion and behaviour

Marco Catani, Flavio Dell’Acqua, Michel Thiebaut de Schotten
Neuroscience & Biobehavioral Reviews. 2013-09-01; 37(8): 1724-1737
DOI: 10.1016/j.neubiorev.2013.07.001

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1. Neurosci Biobehav Rev. 2013 Sep;37(8):1724-37. doi:
10.1016/j.neubiorev.2013.07.001. Epub 2013 Jul 9.

A revised limbic system model for memory, emotion and behaviour.

Catani M(1), Dell’acqua F, Thiebaut de Schotten M.

Author information:
(1)Natbrainlab, Department of Forensic and Neurodevelopmental Sciences, Institute
of Psychiatry, King’s College London, UK. Electronic address:

Emotion, memories and behaviour emerge from the coordinated activities of regions
connected by the limbic system. Here, we propose an update of the limbic model
based on the seminal work of Papez, Yakovlev and MacLean. In the revised model we
identify three distinct but partially overlapping networks: (i) the
Hippocampal-diencephalic and parahippocampal-retrosplenial network dedicated to
memory and spatial orientation; (ii) The temporo-amygdala-orbitofrontal network
for the integration of visceral sensation and emotion with semantic memory and
behaviour; (iii) the default-mode network involved in autobiographical memories
and introspective self-directed thinking. The three networks share cortical nodes
that are emerging as principal hubs in connectomic analysis. This revised network
model of the limbic system reconciles recent functional imaging findings with
anatomical accounts of clinical disorders commonly associated with limbic

Copyright © 2013 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.neubiorev.2013.07.001
PMID: 23850593 [Indexed for MEDLINE]

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