A quantitative-genetic analysis of hippocampal variation in the mouse

W. E. Crusio, G. Genthner-Grimm, H. Schwegler
Journal of Neurogenetics. 2007-01-01; 21(4): 197-208
DOI: 10.1080/01677060701715827

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1. J Neurogenet. 2007 Oct-Dec;21(4):197-208.

A quantitative-genetic analysis of hippocampal variation in the mouse.

Crusio WE(1), Genthner-Grimm G, Schwegler H.

Author information:
(1)Institut für Anthropologie and Humangenetik, Universität Heidelberg,
Heidelberg, FRG.

Republished from
J Neurogenet. 1986 Jul;3(4):203-14.

This report analyses the genetic underpinnings of the proportions of the
hippocampal terminal fields in the mouse at the midseptotemporal level. We used 5
inbred strains and all possible F(1) crosses between them (diallel cross). Broad
heritabilities ranged from 11 to 53%. Additive genetic variation was present for
all phenotypes analyzed. Directional dominance was found for the relative size of
the suprapyramidal mossy fiber terminal field only. For the stratum
lacunosum-moleculare, ambidirectional dominance emerged. These findings suggest
that, in evolutionary history, directional selection has operated for a
proportionally large suprapyramidal terminal field. For all other hippocampal
variables (viz. the relative sizes for the strata oriens, pyramidale, radiatum,
lacunosum-moleculare, CA4, intra- and infrapyramidal mossy fiber terminal field
and the absolute size of the regio inferior) past stabilizing selection was

DOI: 10.1080/01677060701715827
PMID: 18161583

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